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• W2277123120 endingPage "1938" @default.
• W2277123120 startingPage "1928" @default.
• W2277123120 abstract "Abstract Interleukin-6 (IL-6), a product of bone marrow stromal cells (BMSCs), is a growth factor for multiple myeloma (MM) cells. Transforming growth factor-beta1 (TGF-beta1) is also produced by BMSCs and can regulate IL- 6 secretion by several tissues, including BMSCs. The present study was designed to characterize in vitro tumor growth regulation by TGF-beta1 in MM. Sorted CD38+CD45RA- MM cells secreted significantly more TGF- beta1 (8.2 +/- 2.0 ng/mL) than peripheral blood mononuclear cells (P < .001), splenic B cells (P < .001), and CD40 ligand (CD40L) pretreated B cells (P < .05). TGF-beta1 secretion by MM-BMMCs (3.8 +/- 0.9 ng/mL) was significantly greater than by N-BMMCs (1.2 +/- 0.1 ng/mL, P < .001). MM-BMSCs also secreted significantly more TGF-beta1 (6.6 +/- 2.5 ng/mL, n = 11) than N-BMSCs (4.4 +/- 0.6 ng/mL, P < .02, n = 10) and N- BMSC lines (3.9 +/- 0.2 ng/mL, P < .02, n = 6). TGF-beta1 secretion was correlated with IL-6 secretion in MM-BMSCs. Anti-TGF-beta1 monoclonal antibody both blocked IL-6 secretion by BMSCs and inhibited the increments in IL-6 secretion by BMSCs induced by MM cell adhesion. Moreover, exogenous TGF-beta1 upregulated IL-6 secretion by MM-BMSCs, normal BMSCs, and CD38+ CD45RA- MM cells, as well as tumor cell proliferation. This is in contrast to the inhibitory effect of TGF- beta1 on proliferation and Ig secretion of normal splenic B cells. Finally, retinoblastoma proteins (pRB) are constitutively phosphorylated in MM cells; TGF-beta1 either did not alter or increased pRB phosphorylation. pRB are dephosphorylated in splenic B cells and phosphorylated in CD40L triggered B cells in contrast to its effects on MM cells, TGF-beta1 decreased phosphorylation of pRB in CD40L treated B cells. These results suggest that TGF-beta1 is produced in MM by both tumor cells and BMSCs, with related tumore cell growth. Moreover, MM cell growth may be enhanced by resistance of tumor cells to the inhibitory effects of TGF-beta1 on normal B-cell proliferation and Ig secretion." @default.
• W2277123120 created "2016-06-24" @default.
• W2277123120 creator A5006765393 @default.
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• W2277123120 date "1996-03-01" @default.
• W2277123120 modified "2023-10-14" @default.
• W2277123120 title "Transforming growth factor-beta1: differential effects on multiple myeloma versus normal B cells" @default.
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• W2277123120 cites W1499656911 @default.
• W2277123120 cites W1507429946 @default.
• W2277123120 cites W1524114372 @default.
• W2277123120 cites W1528551608 @default.
• W2277123120 cites W1539607590 @default.
• W2277123120 cites W1545424811 @default.
• W2277123120 cites W1562422876 @default.
• W2277123120 cites W1575050480 @default.
• W2277123120 cites W1585820466 @default.
• W2277123120 cites W1594069877 @default.
• W2277123120 cites W1605241473 @default.
• W2277123120 cites W1606990197 @default.
• W2277123120 cites W1627068912 @default.
• W2277123120 cites W187461172 @default.
• W2277123120 cites W192258440 @default.
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• W2277123120 cites W2007768242 @default.
• W2277123120 cites W2008309108 @default.
• W2277123120 cites W2014418134 @default.
• W2277123120 cites W2021107622 @default.
• W2277123120 cites W2021218223 @default.
• W2277123120 cites W2022139778 @default.
• W2277123120 cites W2029681820 @default.
• W2277123120 cites W2036072927 @default.
• W2277123120 cites W2036974053 @default.
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• W2277123120 cites W2074167709 @default.
• W2277123120 cites W2079517510 @default.
• W2277123120 cites W2084746077 @default.
• W2277123120 cites W2088511697 @default.
• W2277123120 cites W2090529961 @default.
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• W2277123120 doi "https://doi.org/10.1182/blood.v87.5.1928.1928" @default.
• W2277123120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8634441" @default.
• W2277123120 hasPublicationYear "1996" @default.
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