FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2277144554> ?p ?o ?g. }

• W2277144554 abstract "The antibody repertoire of each individual is continuously updated by the evolutionary process of B cell receptor mutation and selection. It has recently become possible to gain detailed information concerning this process through high-throughput sequencing. Here, we develop modern statistical molecular evolution methods for the analysis of B cell sequence data, and then apply them to a very deep short-read data set of B cell receptors. We find that the substitution process is conserved across individuals but varies significantly across gene segments. We investigate selection on B cell receptors using a novel method that side-steps the difficulties encountered by previous work in differentiating between selection and motif-driven mutation; this is done through stochastic mapping and empirical Bayes estimators that compare the evolution of in-frame and out-of-frame rearrangements. We use this new method to derive a per-residue map of selection, which provides a more nuanced view of the constraints on framework and variable regions." @default.
• W2277144554 created "2016-06-24" @default.
• W2277144554 creator A5015970952 @default.
• W2277144554 creator A5025387674 @default.
• W2277144554 creator A5067744380 @default.
• W2277144554 creator A5074561782 @default.
• W2277144554 creator A5084752404 @default.
• W2277144554 creator A5089671301 @default.
• W2277144554 date "2014-03-12" @default.
• W2277144554 modified "2023-09-23" @default.
• W2277144554 title "Substitution and site-specific selection driving B cell affinity maturation is consistent across individuals" @default.
• W2277144554 cites W1590636096 @default.
• W2277144554 cites W1643112662 @default.
• W2277144554 cites W1881807356 @default.
• W2277144554 cites W1910623697 @default.
• W2277144554 cites W1920973730 @default.
• W2277144554 cites W1963745142 @default.
• W2277144554 cites W1964480169 @default.
• W2277144554 cites W1993476635 @default.
• W2277144554 cites W1993928780 @default.
• W2277144554 cites W2005566446 @default.
• W2277144554 cites W2005988541 @default.
• W2277144554 cites W2009596137 @default.
• W2277144554 cites W2020905367 @default.
• W2277144554 cites W2022080111 @default.
• W2277144554 cites W2024439539 @default.
• W2277144554 cites W2025403752 @default.
• W2277144554 cites W2028942402 @default.
• W2277144554 cites W2043071551 @default.
• W2277144554 cites W2044223958 @default.
• W2277144554 cites W2050909253 @default.
• W2277144554 cites W2057962126 @default.
• W2277144554 cites W2058311887 @default.
• W2277144554 cites W2058796168 @default.
• W2277144554 cites W2060817590 @default.
• W2277144554 cites W2064313455 @default.
• W2277144554 cites W2068448872 @default.
• W2277144554 cites W2074560222 @default.
• W2277144554 cites W2078950386 @default.
• W2277144554 cites W2082947088 @default.
• W2277144554 cites W2084390276 @default.
• W2277144554 cites W2086439643 @default.
• W2277144554 cites W2086631924 @default.
• W2277144554 cites W2088542711 @default.
• W2277144554 cites W2099762535 @default.
• W2277144554 cites W2103116723 @default.
• W2277144554 cites W2105273832 @default.
• W2277144554 cites W2108512869 @default.
• W2277144554 cites W2108795433 @default.
• W2277144554 cites W2117055771 @default.
• W2277144554 cites W2120431546 @default.
• W2277144554 cites W2123026594 @default.
• W2277144554 cites W2124790653 @default.
• W2277144554 cites W2130362098 @default.
• W2277144554 cites W2136892614 @default.
• W2277144554 cites W2142081242 @default.
• W2277144554 cites W2144368480 @default.
• W2277144554 cites W2144420540 @default.
• W2277144554 cites W2148855679 @default.
• W2277144554 cites W2168175751 @default.
• W2277144554 cites W2169981472 @default.
• W2277144554 hasPublicationYear "2014" @default.
• W2277144554 type Work @default.
• W2277144554 sameAs 2277144554 @default.
• W2277144554 citedByCount "0" @default.
• W2277144554 crossrefType "posted-content" @default.
• W2277144554 hasAuthorship W2277144554A5015970952 @default.
• W2277144554 hasAuthorship W2277144554A5025387674 @default.
• W2277144554 hasAuthorship W2277144554A5067744380 @default.
• W2277144554 hasAuthorship W2277144554A5074561782 @default.
• W2277144554 hasAuthorship W2277144554A5084752404 @default.
• W2277144554 hasAuthorship W2277144554A5089671301 @default.
• W2277144554 hasConcept C107673813 @default.
• W2277144554 hasConcept C154945302 @default.
• W2277144554 hasConcept C207201462 @default.
• W2277144554 hasConcept C41008148 @default.
• W2277144554 hasConcept C54355233 @default.
• W2277144554 hasConcept C70721500 @default.
• W2277144554 hasConcept C81917197 @default.
• W2277144554 hasConcept C86803240 @default.
• W2277144554 hasConceptScore W2277144554C107673813 @default.
• W2277144554 hasConceptScore W2277144554C154945302 @default.
• W2277144554 hasConceptScore W2277144554C207201462 @default.
• W2277144554 hasConceptScore W2277144554C41008148 @default.
• W2277144554 hasConceptScore W2277144554C54355233 @default.
• W2277144554 hasConceptScore W2277144554C70721500 @default.
• W2277144554 hasConceptScore W2277144554C81917197 @default.
• W2277144554 hasConceptScore W2277144554C86803240 @default.
• W2277144554 hasLocation W22771445541 @default.
• W2277144554 hasOpenAccess W2277144554 @default.
• W2277144554 hasPrimaryLocation W22771445541 @default.
• W2277144554 hasRelatedWork W1513151891 @default.
• W2277144554 hasRelatedWork W1986219345 @default.
• W2277144554 hasRelatedWork W1992358035 @default.
• W2277144554 hasRelatedWork W1999967516 @default.
• W2277144554 hasRelatedWork W2112516369 @default.
• W2277144554 hasRelatedWork W2149608597 @default.
• W2277144554 hasRelatedWork W2154131901 @default.
• W2277144554 hasRelatedWork W2164941383 @default.
• W2277144554 hasRelatedWork W2230992388 @default.

• next