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- W2277309166 abstract "Introduction: Ulcerative colitis is one of the entities that integrates inflammatory bowel disease. It is a chronic disease that usually begins in the rectum and may extend, by continuity, to more proximal segments of the colon. There have been advances in the knowledge of predisposing factors. The surgery is proposed in patients at risk of colorectal cancer or refractory to medical treatment and also in situations of severe colitis with uncontrollable bleeding or progression to toxic megacolon. The most serious hepatobiliary pathology that is associated with ulcerative colitis is primary sclerosing cholangitis. Case report: Female patient, 30 years old that was diagnosed with primary sclerosing cholangitis and autoimmune hepatitis at age 14 (1997), which conditioned liver transplant in 2005. At 21 years old (in 2004) the diagnosis of ulcerative Colitis was established and medical therapy was instituted with good response for 6 years. In May 2010 the patient began corticosteroid therapy but the disease activity remained, with exudative ulcers, erosions and subepithelial hemorrhage observed in the endoscopy. In April 2011 the patient underwent total colectomy with ileostomy terminal and in 2013 reconstructive proctectomy with ileoanal pouch S was performed. Conclusion: The diagnosis of ulcerative colitis is based on clinical findings and is supported by endoscopy and histology. The present case was the basis for relating the onset and course of ulcerative colitis associated with other autoimmune diseases in the same patient: autoimmune hepatitis and sclerosing cholangitis, which culminated in a liver transplant. However, the clinical history does not corroborate unequivocally the existence of a relationship in the activity of these diseases. Surgery has limited indications, but was the definitive treatment for this patient, after medical therapy failure." @default.
- W2277309166 created "2016-06-24" @default.
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- W2277309166 date "2014-07-14" @default.
- W2277309166 modified "2023-09-26" @default.
- W2277309166 title "Colite-ulcerosa - a propósito de um caso clínico" @default.
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