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- W2277334224 abstract "Multiple Sclerosis (MS) is a disease of the central nervous system that affects individuals 20 - 40 years old. MS is thought to be an autoimmune disease in which T cells attack and destroy the myelin sheath surrounding neurons. Demyelinated neurons have a reduced capacity to transmit electrical impulses, causing symptoms from loss of muscle control to memory loss. One protein thought to play a role in MS is B7-2, a member of a family of proteins that regulate T cell functions expressed by antigen presenting cells (APC). Generation of an immune response by T cells requires two signals: binding of the T-cell receptor to the antigen/MHC complex on APC and binding of B7-1 to CD28 on the T cells. B7-2 is thought to be involved in suppression of the T cell response through binding to CTLA-4. Research using the mouse model of MS, EAE, demonstrated that injection of B7-2 specific antibodies resulted in a more severe disease course. These data suggest that B7-2 plays a role in negative regulation of the immune response during EAE, possibly by binding CTLA-4. To investigate how B7-2 interacts with CTLA-4, we developed a physical model of B7-2 based on its crystal structure (1ncn.pdb) using 3D printing technology that highlights the protein's β sheet structure and amino acids thought to be important in CTLA-4 binding. This model was built as a part of the SMART team program at Milwaukee School of Engineering. Supported by a grant from NIH-NCRR-SEPA." @default.
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- W2277334224 date "2009-04-01" @default.
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- W2277334224 title "The Role of B7‐2 in the Regulation of T cell Activation in Multiple Sclerosis" @default.
- W2277334224 doi "https://doi.org/10.1096/fasebj.23.1_supplement.lb317" @default.
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