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• W2277409206 abstract "The pathophysiology of irritable bowel syndrome (IBS) remains unclear. Here we investigated the microbiome of a large cohort of patients to identify specific signatures for IBS subtypes. We examined the microbiome of 113 patients with IBS and 66 healthy controls. A subset of these participants provided two samples one month apart. We analyzed a total of 273 fecal samples, generating more than 20 million 16S rRNA sequences. In patients with IBS, a significantly lower microbial diversity was associated with a lower relative abundance of butyrate-producing bacteria (P = 0.002; q < 0.06), in particular in patients with IBS-D and IBS-M. IBS patients who did not receive any treatment harboured a lower abundance of Methanobacteria compared to healthy controls (P = 0.005; q = 0.05). Furthermore, significant correlations were observed between several bacterial taxa and sensation of flatulence and abdominal pain (P < 0.05). Altogether, our findings showed that IBS-M and IBS-D patients are characterized by a reduction of butyrate producing bacteria, known to improve intestinal barrier function, and a reduction of methane producing microorganisms a major mechanism of hydrogen disposal in the human colon, which could explain excess of abdominal gas in IBS." @default.
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• W2277409206 date "2015-08-04" @default.
• W2277409206 modified "2023-10-16" @default.
• W2277409206 title "Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome" @default.
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• W2277409206 doi "https://doi.org/10.1038/srep12693" @default.
• W2277409206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4523847" @default.
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