Matches in SemOpenAlex for { <https://semopenalex.org/work/W2277539591> ?p ?o ?g. }
- W2277539591 endingPage "1420" @default.
- W2277539591 startingPage "1408" @default.
- W2277539591 abstract "Abstract Endocrine-disrupting chemicals are prevalent in the environment and can impair reproductive success by affecting the hypothalamic-pituitary-gonadal axis. The developing pituitary gland is sensitive to exposure to endocrine-disrupting chemicals, such as bisphenol A (BPA), and sex-specific effects can occur. However, effects on the critical window of neonatal pituitary gland development in mice have not been explored. Therefore, this study determined baseline gene expression in male and female pituitaries and consequences of environmental exposure to 17β-estradiol (E2) and BPA on transcription of genes exhibiting sex differences during the neonatal period. Through microarray and quantitative RT-PCR analysis of pituitaries at postnatal day (PND)1, 3 genes were differentially expressed between males and females: Lhb, Fshb, and intracellular adhesion molecule-5 (Icam5). To see whether E2 and BPA exposure regulates these genes, pituitaries were cultured at PND1 with 10−8M E2 or 4.4 × 10−6M BPA. E2 decreased expression of Lhb, Fshb, and Icam5 mRNA in females but only significantly decreased expression of Icam5 in males. BPA decreased expression of Icam5 similarly to E2, but it did not affect Lhb or Fshb. Importantly, in vivo exposure to 50-μg/kg · d E2 from PND0 to PND7 decreased expression of Lhb, Fshb, and Icam5 mRNA in both males and females, whereas 50-mg/kg · d BPA exposure during the same time frame decreased expression of Icam5 in females only. Overall, we have uncovered that genes differentially expressed between the sexes can be regulated in part by hormonal and chemical signals in vivo and directly at the pituitary and can be regulated in a sex-specific manner." @default.
- W2277539591 created "2016-06-24" @default.
- W2277539591 creator A5009204351 @default.
- W2277539591 creator A5040156100 @default.
- W2277539591 creator A5043245241 @default.
- W2277539591 creator A5061761705 @default.
- W2277539591 creator A5076450562 @default.
- W2277539591 date "2016-01-20" @default.
- W2277539591 modified "2023-10-13" @default.
- W2277539591 title "Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A" @default.
- W2277539591 cites W1527098129 @default.
- W2277539591 cites W1698366670 @default.
- W2277539591 cites W1966738994 @default.
- W2277539591 cites W1968179768 @default.
- W2277539591 cites W1968381333 @default.
- W2277539591 cites W1970609334 @default.
- W2277539591 cites W1976381556 @default.
- W2277539591 cites W1979637368 @default.
- W2277539591 cites W1980992747 @default.
- W2277539591 cites W1985676469 @default.
- W2277539591 cites W1987736972 @default.
- W2277539591 cites W1990752381 @default.
- W2277539591 cites W1993497469 @default.
- W2277539591 cites W1993744150 @default.
- W2277539591 cites W1996350580 @default.
- W2277539591 cites W1996583872 @default.
- W2277539591 cites W2003316529 @default.
- W2277539591 cites W2009409720 @default.
- W2277539591 cites W2010206469 @default.
- W2277539591 cites W2013830277 @default.
- W2277539591 cites W2014166259 @default.
- W2277539591 cites W2016682394 @default.
- W2277539591 cites W2020121188 @default.
- W2277539591 cites W2021501402 @default.
- W2277539591 cites W2027064977 @default.
- W2277539591 cites W2029377403 @default.
- W2277539591 cites W2033513709 @default.
- W2277539591 cites W2034306249 @default.
- W2277539591 cites W2035699435 @default.
- W2277539591 cites W2037790468 @default.
- W2277539591 cites W2039269175 @default.
- W2277539591 cites W2039466440 @default.
- W2277539591 cites W2039901936 @default.
- W2277539591 cites W2048937754 @default.
- W2277539591 cites W2049970571 @default.
- W2277539591 cites W2052297021 @default.
- W2277539591 cites W2052517186 @default.
- W2277539591 cites W2066546360 @default.
- W2277539591 cites W2072593835 @default.
- W2277539591 cites W2079104378 @default.
- W2277539591 cites W2081161251 @default.
- W2277539591 cites W2082624269 @default.
- W2277539591 cites W2085556797 @default.
- W2277539591 cites W2085868117 @default.
- W2277539591 cites W2088684987 @default.
- W2277539591 cites W2088927950 @default.
- W2277539591 cites W2090364077 @default.
- W2277539591 cites W2100449935 @default.
- W2277539591 cites W2101629883 @default.
- W2277539591 cites W2103174554 @default.
- W2277539591 cites W2107660405 @default.
- W2277539591 cites W2108241608 @default.
- W2277539591 cites W2112484512 @default.
- W2277539591 cites W2115537559 @default.
- W2277539591 cites W2124306293 @default.
- W2277539591 cites W2131760518 @default.
- W2277539591 cites W2132041548 @default.
- W2277539591 cites W2132180344 @default.
- W2277539591 cites W2133925293 @default.
- W2277539591 cites W2135182684 @default.
- W2277539591 cites W2140179339 @default.
- W2277539591 cites W2141285552 @default.
- W2277539591 cites W2143323131 @default.
- W2277539591 cites W2144727302 @default.
- W2277539591 cites W2150771326 @default.
- W2277539591 cites W2151441337 @default.
- W2277539591 cites W2154410429 @default.
- W2277539591 cites W2160240007 @default.
- W2277539591 cites W2162830803 @default.
- W2277539591 cites W2166781998 @default.
- W2277539591 cites W2170121431 @default.
- W2277539591 cites W2223389223 @default.
- W2277539591 cites W2885139221 @default.
- W2277539591 cites W3144944386 @default.
- W2277539591 doi "https://doi.org/10.1210/en.2015-1521" @default.
- W2277539591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4816737" @default.
- W2277539591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26789235" @default.
- W2277539591 hasPublicationYear "2016" @default.
- W2277539591 type Work @default.
- W2277539591 sameAs 2277539591 @default.
- W2277539591 citedByCount "22" @default.
- W2277539591 countsByYear W22775395912016 @default.
- W2277539591 countsByYear W22775395912017 @default.
- W2277539591 countsByYear W22775395912018 @default.
- W2277539591 countsByYear W22775395912019 @default.
- W2277539591 countsByYear W22775395912020 @default.
- W2277539591 countsByYear W22775395912021 @default.
- W2277539591 countsByYear W22775395912022 @default.