FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2277622314> ?p ?o ?g. }

• W2277622314 endingPage "e0148957" @default.
• W2277622314 startingPage "e0148957" @default.
• W2277622314 abstract "Numerous prognostic gene expression signatures have been recently described. Among the signatures there is variation in the constituent genes that are utilized. We aim to evaluate prognostic concordance among eight gene expression signatures, on a large dataset of ER positive HER2 negative breast cancers.We analysed the performance of eight gene expression signatures on six different datasets of ER+ HER2- breast cancers. Survival analyses were performed using the Kaplan-Meier estimate of survival function. We assessed discrimination and concordance between the 8 signatures on survival and recurrence rates The Nottingham Prognostic Index (NPI) was used to to stratify the risk of recurrence/death.The discrimination ability of the whole signatures, showed fair discrimination performances, with AUC ranging from 0.64 (95%CI 0.55-0.73 for the 76-genes signatures, to 0.72 (95%CI 0.64-0.8) for the Molecular Prognosis Index T17. Low concordance was found in predicting events in the intermediate and high-risk group, as defined by the NPI. Low risk group was the only subgroup with a good signatures concordance.Genomic signatures may be a good option to predict prognosis as most of them perform well at the population level. They exhibit, however, a high degree of discordance in the intermediate and high-risk groups. The major benefit that we could expect from gene expression signatures is the standardization of proliferation assessment." @default.
• W2277622314 created "2016-06-24" @default.
• W2277622314 creator A5000923474 @default.
• W2277622314 creator A5001576142 @default.
• W2277622314 creator A5003301011 @default.
• W2277622314 creator A5031325232 @default.
• W2277622314 creator A5034800178 @default.
• W2277622314 creator A5071567585 @default.
• W2277622314 date "2016-02-19" @default.
• W2277622314 modified "2023-09-24" @default.
• W2277622314 title "Low Concordance between Gene Expression Signatures in ER Positive HER2 Negative Breast Carcinoma Could Impair Their Clinical Application" @default.
• W2277622314 cites W1607267312 @default.
• W2277622314 cites W1973803589 @default.
• W2277622314 cites W1983271078 @default.
• W2277622314 cites W1989222913 @default.
• W2277622314 cites W1996624321 @default.
• W2277622314 cites W2002246796 @default.
• W2277622314 cites W2044702943 @default.
• W2277622314 cites W2049129660 @default.
• W2277622314 cites W2074465378 @default.
• W2277622314 cites W2076356585 @default.
• W2277622314 cites W2080057019 @default.
• W2277622314 cites W2082833890 @default.
• W2277622314 cites W2085256503 @default.
• W2277622314 cites W2091311891 @default.
• W2277622314 cites W2091947792 @default.
• W2277622314 cites W2095900239 @default.
• W2277622314 cites W2096079397 @default.
• W2277622314 cites W2105882193 @default.
• W2277622314 cites W2113344831 @default.
• W2277622314 cites W2113957930 @default.
• W2277622314 cites W2118343282 @default.
• W2277622314 cites W2118413367 @default.
• W2277622314 cites W2128957040 @default.
• W2277622314 cites W2128985829 @default.
• W2277622314 cites W2130598050 @default.
• W2277622314 cites W2132893003 @default.
• W2277622314 cites W2137028370 @default.
• W2277622314 cites W2137053366 @default.
• W2277622314 cites W2150134401 @default.
• W2277622314 cites W2150533948 @default.
• W2277622314 cites W2150671673 @default.
• W2277622314 cites W2152121590 @default.
• W2277622314 cites W2156711378 @default.
• W2277622314 cites W2157132621 @default.
• W2277622314 cites W2157446225 @default.
• W2277622314 cites W2159809499 @default.
• W2277622314 cites W2160377567 @default.
• W2277622314 cites W2160450758 @default.
• W2277622314 cites W2163563958 @default.
• W2277622314 cites W2165638006 @default.
• W2277622314 cites W2170140374 @default.
• W2277622314 cites W2423342352 @default.
• W2277622314 cites W4245024447 @default.
• W2277622314 doi "https://doi.org/10.1371/journal.pone.0148957" @default.
• W2277622314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4760978" @default.
• W2277622314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26895349" @default.
• W2277622314 hasPublicationYear "2016" @default.
• W2277622314 type Work @default.
• W2277622314 sameAs 2277622314 @default.
• W2277622314 citedByCount "9" @default.
• W2277622314 countsByYear W22776223142016 @default.
• W2277622314 countsByYear W22776223142017 @default.
• W2277622314 countsByYear W22776223142018 @default.
• W2277622314 countsByYear W22776223142019 @default.
• W2277622314 countsByYear W22776223142021 @default.
• W2277622314 countsByYear W22776223142022 @default.
• W2277622314 crossrefType "journal-article" @default.
• W2277622314 hasAuthorship W2277622314A5000923474 @default.
• W2277622314 hasAuthorship W2277622314A5001576142 @default.
• W2277622314 hasAuthorship W2277622314A5003301011 @default.
• W2277622314 hasAuthorship W2277622314A5031325232 @default.
• W2277622314 hasAuthorship W2277622314A5034800178 @default.
• W2277622314 hasAuthorship W2277622314A5071567585 @default.
• W2277622314 hasBestOaLocation W22776223141 @default.
• W2277622314 hasConcept C104317684 @default.
• W2277622314 hasConcept C10515644 @default.
• W2277622314 hasConcept C121608353 @default.
• W2277622314 hasConcept C126322002 @default.
• W2277622314 hasConcept C143998085 @default.
• W2277622314 hasConcept C150194340 @default.
• W2277622314 hasConcept C160798450 @default.
• W2277622314 hasConcept C18431079 @default.
• W2277622314 hasConcept C2779733811 @default.
• W2277622314 hasConcept C2779740036 @default.
• W2277622314 hasConcept C2908647359 @default.
• W2277622314 hasConcept C530470458 @default.
• W2277622314 hasConcept C54355233 @default.
• W2277622314 hasConcept C60644358 @default.
• W2277622314 hasConcept C71924100 @default.
• W2277622314 hasConcept C86803240 @default.
• W2277622314 hasConcept C99454951 @default.
• W2277622314 hasConceptScore W2277622314C104317684 @default.
• W2277622314 hasConceptScore W2277622314C10515644 @default.
• W2277622314 hasConceptScore W2277622314C121608353 @default.
• W2277622314 hasConceptScore W2277622314C126322002 @default.
• W2277622314 hasConceptScore W2277622314C143998085 @default.
• W2277622314 hasConceptScore W2277622314C150194340 @default.

• next