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- W2277695004 abstract "<h3>Objectives</h3> <i>Chlamydia trachomatis</i> is the most common bacterial sexually transmitted infection and is frequently asymptomatic; ocular <i>C. trachomatis</i> strains cause trachoma. Mass drug administration (MDA) of azithromycin for trachoma might also reduce the prevalence of genital <i>C. trachomatis</i>. In a survey conducted in the Solomon Islands in 2014, prior to MDA, the prevalence of genital <i>C. trachomatis</i> was 20.3% (95% CI 15.9% to 25.4%). We conducted a survey to establish the impact of MDA with azithromycin on genital <i>C. trachomatis</i>. <h3>Methods</h3> Women attending three community outpatient clinics, predominantly for antenatal care, 10 months after MDA with azithromycin given for trachoma elimination, were enrolled in this survey. Self-taken high vaginal swabs were for <i>C. trachomatis</i> and <i>Neisseria gonorrhoeae</i> using the BD Probetec strand displacement assay. <h3>Results</h3> 298 women were enrolled. <i>C. trachomatis</i> infection was diagnosed in 43 women (14.4%, 95% CI 10.6% to 18.9%) and <i>N. gonorrhoeae</i> in 9 (3%, 95% CI 1.4% to 5.7%). The age-adjusted OR for <i>C. trachomatis</i> infection was consistent with a significant decrease in the prevalence of <i>C. trachomatis</i> following MDA (OR 0.58, 95% CI 0.37 to 0.94, p=0.027). There was no change in the prevalence of <i>N. gonorrhoeae</i> between following MDA (OR 0.51, 95% CI 0.22 to 1.22, p=0.13). <h3>Conclusions</h3> This study demonstrated a 40% reduction in the age-adjusted prevalence of genital <i>C. trachomatis</i> infection following azithromycin MDA for trachoma elimination." @default.
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- W2277695004 date "2016-02-17" @default.
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- W2277695004 title "Mass drug administration of azithromycin for trachoma reduces the prevalence of genital<i>Chlamydia trachomatis</i>infection in the Solomon Islands" @default.
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- W2277695004 doi "https://doi.org/10.1136/sextrans-2015-052439" @default.
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