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- W2277698540 abstract "Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits. In driver thalamocortical (TC) synaptic populations, STP is dominated by depression during stimulation from rest. However, during ongoing stimulation, lemniscal TC connections onto layer 4 neurons in mouse barrel cortex express variable STP. Each synapse responds to input trains with a distinct pattern of depression or facilitation around its mean steady-state response. As a result, in common with other synaptic populations, lemniscal TC synapses express diverse rather than uniform dynamics, allowing for a rich representation of temporally varying stimuli. Here, we show that this STP diversity is regulated presynaptically. Presynaptic adenosine receptors of the A1R type, but not kainate receptors (KARs), modulate STP behavior. Blocking the receptors does not eliminate diversity, indicating that diversity is related to heterogeneous expression of multiple mechanisms in the pathway from presynaptic calcium influx to neurotransmitter release." @default.
- W2277698540 created "2016-06-24" @default.
- W2277698540 creator A5029897204 @default.
- W2277698540 creator A5039819263 @default.
- W2277698540 creator A5062580902 @default.
- W2277698540 date "2016-02-23" @default.
- W2277698540 modified "2023-10-17" @default.
- W2277698540 title "Presynaptic Adenosine Receptor-Mediated Regulation of Diverse Thalamocortical Short-Term Plasticity in the Mouse Whisker Pathway" @default.
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- W2277698540 doi "https://doi.org/10.3389/fncir.2016.00009" @default.
- W2277698540 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4763074" @default.
- W2277698540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26941610" @default.
- W2277698540 hasPublicationYear "2016" @default.
- W2277698540 type Work @default.
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