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- W2277773384 abstract "e22153 Background: p73 is a p53 homologue that has been implicated both as a tumor suppressor and oncogene. While known to play a role in the apoptotic response, homozygous p73 knockout mice have not shown an increased susceptibility to tumor formation. However, recent literature suggests that p73 dysregulation may play a role in retinoblastoma, ovarian and bladder cancer. We sought to correlate p73 status with clinical-pathologic factors including mismatch repair status, in a large cohort of comprehensively staged endometrial cancers. Methods: Primary endometrial and colon cancers were used to create a tissue microarray (TMA). Two-hundred eight endometrial specimens were available for evaluation. Immunohistochemistry with p73 was performed using commercial available antibodies. Positive staining was defined as > 10% cells having positive nuclear staining. Microsatellite (MSI) instability testing as well as IHC for p53 had been previously performed. Statistical analysis was performed using Fisher's exact test. Results: In six non-neoplastic control endometrial samples examined, p73 appears to stain mainly surface epithelial cell nuclei and superficial glands. p73 expression was identified in 71 (34%) of endometrial cancer specimens. There was no correlation between p73 status and histology, stage, grade or MSI status. Strong correlation that was noted between p53 status and p73 status. Ninety-eight (71%) of the 137 p73 negative tumors were noted to be wildtype(negative staining) for p53 (p<.001). However, when the (-)p73 (+)p53 and (+) p73 (+)p53 phenotypes were examined separately, there was no correlation with stage or grade. Conclusions: p73 is a p53 homologue with uncertain potential as an oncogene and tumor suppressor gene. To date, we offer the largest study of p73 expression in comprehensively staged endometrial cancer. While we show significant loss of p73 expression among cancer specimens, we were unable to demonstrate a relationship between p73 and clinical factors. However, an interesting correlation between p53 status and p73 does appear. The potential role for p73 and p53 in the apoptotic response to cytotoxic chemotherapy is interesting and deserves further study. No significant financial relationships to disclose." @default.
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- W2277773384 date "2009-05-20" @default.
- W2277773384 modified "2023-10-17" @default.
- W2277773384 title "Clinical and pathologic correlation of p73 expression in surgically staged endometrial cancer" @default.
- W2277773384 doi "https://doi.org/10.1200/jco.2009.27.15_suppl.e22153" @default.
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