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- W2277796958 abstract "Objective To detect IL-6,IL-12,IFN-γand IL-10 in patients with hepatic flares and study their association with hepatic flares and the degree of severity in chronic hepatitis B patients.Methods 154 chronic hepatitis B patients with hepatic flare were determined for the levels of IL-6,IL-12,IFN-γ and IL-10 by ELISA.Liver functions and HBV DNA were also measured.Results The age of chronic hepatitis B patients with hepatic flare was older,HBV DNA level was lower,the levels pro-inflammatory and inflammatory cytokines were higher than those immune tolerant patients.In the severe hepatitis group,the IL-6 level(179.80±134.96)pg /ml was higher than that of non-severe group(108.80±113.23)pg /ml(P0.05),but the IL-10 level(12.80±4.96)mg /ml was lower than that of the non-severe group(20.33±7.35)pg /ml(P0.05).Conclusion The inflammatory cytokoines may play important role in hepatic flares in patients with chronic HBV infection.IL-6 may contribute to hepatic injury,but IL10 may have important role on avoiding over immunopathogenesis." @default.
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- W2277796958 date "2010-01-01" @default.
- W2277796958 modified "2023-09-23" @default.
- W2277796958 title "The Correlation of the Changes of IL-6 and IL-10 with Liver Function Failure in Chronic Hepatitis B Patients with Hepatic Flare" @default.
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