Matches in SemOpenAlex for { <https://semopenalex.org/work/W2277851873> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2277851873 endingPage "1463" @default.
- W2277851873 startingPage "1453" @default.
- W2277851873 abstract "Ureido carbonyl-labeled 14C-biotin was injected intraperitoneally into young adult, male rats to study the excretion and degradation of the vitamin. After milligram quantities of the radioactive biotin were injected, the intact vitamin was found to be almost completely excreted in the urine within 24 hours. The initial excretion rate decreases with decreasing amounts of biotin administered. This initial decrease is even more marked with biotin-depleted rats. Biotin-depleted rats, treated with succinyl sulfathiazole and penicillin, were given a single injection of radioactive biotin (0.5 µg/100 g body weight). Urine was fractionated for radioactive biotin metabolites, four of which have been identified as follows: the d- and l-sulfoxides of biotin, bisnorbiotin, and a neutral ketone. No radioactive CO2 and urea could be detected. Also, liver homogenates were incubated with carbonyl-labeled biotin at 37° for 40 or 60 minutes, with or without aeration. Under O2-limiting conditions, the same four biotin metabolites were also found, but in different proportions. With aeration, the amount of biotin sulfoxides increased; also, trace amounts of radioactive CO2 and urea were detected. Therefore, the rat has the ability to metabolize the vitamin via at least partial β-oxidation of the side chain and to effect some oxidation of the thioether sulfur to sulfoxides. Under physiological conditions, however, the metabolism of biotin in rats, unlike certain bacteria, does not include extensive cleavage of the ring structure of the molecule." @default.
- W2277851873 created "2016-06-24" @default.
- W2277851873 creator A5054156016 @default.
- W2277851873 creator A5064778502 @default.
- W2277851873 creator A5065375909 @default.
- W2277851873 date "1972-11-01" @default.
- W2277851873 modified "2023-10-10" @default.
- W2277851873 title "Metabolism of Carbonyl-labeled 14C-Biotin in the Rat" @default.
- W2277851873 cites W1529852090 @default.
- W2277851873 cites W1545204869 @default.
- W2277851873 cites W1585675907 @default.
- W2277851873 cites W1590692348 @default.
- W2277851873 cites W1597333617 @default.
- W2277851873 cites W1608761121 @default.
- W2277851873 cites W172461419 @default.
- W2277851873 cites W1818763050 @default.
- W2277851873 cites W1872776126 @default.
- W2277851873 cites W1966811314 @default.
- W2277851873 cites W1975134657 @default.
- W2277851873 cites W1993006396 @default.
- W2277851873 cites W1995411991 @default.
- W2277851873 cites W2013933880 @default.
- W2277851873 cites W2019811326 @default.
- W2277851873 cites W2026442894 @default.
- W2277851873 cites W2026912546 @default.
- W2277851873 cites W2059239868 @default.
- W2277851873 cites W2079698396 @default.
- W2277851873 cites W2087398816 @default.
- W2277851873 cites W2162584448 @default.
- W2277851873 cites W2295484893 @default.
- W2277851873 cites W2324019649 @default.
- W2277851873 cites W2327191845 @default.
- W2277851873 cites W4231961160 @default.
- W2277851873 cites W4251765500 @default.
- W2277851873 cites W47131544 @default.
- W2277851873 doi "https://doi.org/10.1093/jn/102.11.1453" @default.
- W2277851873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5081681" @default.
- W2277851873 hasPublicationYear "1972" @default.
- W2277851873 type Work @default.
- W2277851873 sameAs 2277851873 @default.
- W2277851873 citedByCount "44" @default.
- W2277851873 countsByYear W22778518732012 @default.
- W2277851873 countsByYear W22778518732016 @default.
- W2277851873 countsByYear W22778518732020 @default.
- W2277851873 crossrefType "journal-article" @default.
- W2277851873 hasAuthorship W2277851873A5054156016 @default.
- W2277851873 hasAuthorship W2277851873A5064778502 @default.
- W2277851873 hasAuthorship W2277851873A5065375909 @default.
- W2277851873 hasBestOaLocation W22778518731 @default.
- W2277851873 hasConcept C10146269 @default.
- W2277851873 hasConcept C185592680 @default.
- W2277851873 hasConcept C2776203871 @default.
- W2277851873 hasConcept C2776294945 @default.
- W2277851873 hasConcept C2776940978 @default.
- W2277851873 hasConcept C2777477808 @default.
- W2277851873 hasConcept C2778204606 @default.
- W2277851873 hasConcept C2780026642 @default.
- W2277851873 hasConcept C2780365088 @default.
- W2277851873 hasConcept C43617362 @default.
- W2277851873 hasConcept C55493867 @default.
- W2277851873 hasConcept C62231903 @default.
- W2277851873 hasConceptScore W2277851873C10146269 @default.
- W2277851873 hasConceptScore W2277851873C185592680 @default.
- W2277851873 hasConceptScore W2277851873C2776203871 @default.
- W2277851873 hasConceptScore W2277851873C2776294945 @default.
- W2277851873 hasConceptScore W2277851873C2776940978 @default.
- W2277851873 hasConceptScore W2277851873C2777477808 @default.
- W2277851873 hasConceptScore W2277851873C2778204606 @default.
- W2277851873 hasConceptScore W2277851873C2780026642 @default.
- W2277851873 hasConceptScore W2277851873C2780365088 @default.
- W2277851873 hasConceptScore W2277851873C43617362 @default.
- W2277851873 hasConceptScore W2277851873C55493867 @default.
- W2277851873 hasConceptScore W2277851873C62231903 @default.
- W2277851873 hasIssue "11" @default.
- W2277851873 hasLocation W22778518731 @default.
- W2277851873 hasLocation W22778518732 @default.
- W2277851873 hasOpenAccess W2277851873 @default.
- W2277851873 hasPrimaryLocation W22778518731 @default.
- W2277851873 hasRelatedWork W1578848295 @default.
- W2277851873 hasRelatedWork W1840481408 @default.
- W2277851873 hasRelatedWork W2009807520 @default.
- W2277851873 hasRelatedWork W2011868545 @default.
- W2277851873 hasRelatedWork W2049773694 @default.
- W2277851873 hasRelatedWork W2077547099 @default.
- W2277851873 hasRelatedWork W2342638191 @default.
- W2277851873 hasRelatedWork W247628758 @default.
- W2277851873 hasRelatedWork W2971012003 @default.
- W2277851873 hasRelatedWork W2181916269 @default.
- W2277851873 hasVolume "102" @default.
- W2277851873 isParatext "false" @default.
- W2277851873 isRetracted "false" @default.
- W2277851873 magId "2277851873" @default.
- W2277851873 workType "article" @default.