Matches in SemOpenAlex for { <https://semopenalex.org/work/W2277882234> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2277882234 abstract "MicroRNAs (miRNAs) are small, endogenous non-coding RNA molecules that interact with messenger RNAs to direct their post-transcriptional repression. Like messenger RNAs, miRNAs exhibit distinct spatiotemporal expression signatures. The human brain, marked by tremendous structural and functional complexity, has an especially diverse miRNA expression profile. Altered expression or function of miRNAs has been linked to several neuropsychiatric disorders, including Alzheimer’s disease, Tourette’s syndrome, and Schizophrenia. Schizophrenia is a debilitating psychiatric disorder that affects 0.5-1% of the world’s population. Family and twin studies suggest a strong genetic component to the disease, but efforts to isolate causal variants have been hampered by genetic heterogeneity, as well as interacting environmental factors. The underlying goal of this dissertation research is to investigate altered miRNA regulatory networks in individuals with schizophrenia spectrum disorders. The work presented herein begins with a miRNA expression atlas of the developing human brain. Tissue samples representing fetal, early postnatal, and adult time points (n = 48 total) were analyzed using microarrays, and 312 miRNAs were classified according to their temporal expression patterns. This work goes on to describe the development of a multiplexed, bead-based SNP genotyping assay which was applied in a family-based genetic association study of the miRNA processing gene DGCR8. Comprehensive miRNA expression analysis of post-mortem brain tissue samples from subjects with schizophrenia, subjects with bipolar disorder, and psychiatrically healthy controls (n = 35 each group) revealed significant under-expression of several miRNAs in individuals with major psychosis, substantiating a proposed defect in miRNA processing. A pattern-based algorithm called miRSNiPer was developed, and used to predict SNPs that alter miRNA binding sites. A panel of 48 putative “miRSNPs” were genotyped in 25 extended pedigrees, and a SNP in the 3’UTR of H3F3B showed evidence of association (PPLD = 17%) to schizophrenia and schizoaffective disorder. Finally, the miRSNiPer algorithm was used to identify enriched genes and pathways among the targets of mis-expressed miRNAs.%%%%" @default.
- W2277882234 created "2016-06-24" @default.
- W2277882234 creator A5046673522 @default.
- W2277882234 date "2009-01-01" @default.
- W2277882234 modified "2023-09-23" @default.
- W2277882234 title "Altered microRNA regulatory networks in individuals with schizophrenia" @default.
- W2277882234 doi "https://doi.org/10.7282/t3891610" @default.
- W2277882234 hasPublicationYear "2009" @default.
- W2277882234 type Work @default.
- W2277882234 sameAs 2277882234 @default.
- W2277882234 citedByCount "0" @default.
- W2277882234 crossrefType "journal-article" @default.
- W2277882234 hasAuthorship W2277882234A5046673522 @default.
- W2277882234 hasConcept C104317684 @default.
- W2277882234 hasConcept C118552586 @default.
- W2277882234 hasConcept C145059251 @default.
- W2277882234 hasConcept C150194340 @default.
- W2277882234 hasConcept C15744967 @default.
- W2277882234 hasConcept C18431079 @default.
- W2277882234 hasConcept C2776412080 @default.
- W2277882234 hasConcept C2908647359 @default.
- W2277882234 hasConcept C54355233 @default.
- W2277882234 hasConcept C60644358 @default.
- W2277882234 hasConcept C70721500 @default.
- W2277882234 hasConcept C71924100 @default.
- W2277882234 hasConcept C86803240 @default.
- W2277882234 hasConcept C99454951 @default.
- W2277882234 hasConceptScore W2277882234C104317684 @default.
- W2277882234 hasConceptScore W2277882234C118552586 @default.
- W2277882234 hasConceptScore W2277882234C145059251 @default.
- W2277882234 hasConceptScore W2277882234C150194340 @default.
- W2277882234 hasConceptScore W2277882234C15744967 @default.
- W2277882234 hasConceptScore W2277882234C18431079 @default.
- W2277882234 hasConceptScore W2277882234C2776412080 @default.
- W2277882234 hasConceptScore W2277882234C2908647359 @default.
- W2277882234 hasConceptScore W2277882234C54355233 @default.
- W2277882234 hasConceptScore W2277882234C60644358 @default.
- W2277882234 hasConceptScore W2277882234C70721500 @default.
- W2277882234 hasConceptScore W2277882234C71924100 @default.
- W2277882234 hasConceptScore W2277882234C86803240 @default.
- W2277882234 hasConceptScore W2277882234C99454951 @default.
- W2277882234 hasLocation W22778822341 @default.
- W2277882234 hasOpenAccess W2277882234 @default.
- W2277882234 hasPrimaryLocation W22778822341 @default.
- W2277882234 hasRelatedWork W1995814171 @default.
- W2277882234 hasRelatedWork W2008094492 @default.
- W2277882234 hasRelatedWork W2013106911 @default.
- W2277882234 hasRelatedWork W2023521045 @default.
- W2277882234 hasRelatedWork W2047721309 @default.
- W2277882234 hasRelatedWork W2054428260 @default.
- W2277882234 hasRelatedWork W2066408068 @default.
- W2277882234 hasRelatedWork W2084446450 @default.
- W2277882234 hasRelatedWork W2296671803 @default.
- W2277882234 hasRelatedWork W2417006909 @default.
- W2277882234 hasRelatedWork W2472422767 @default.
- W2277882234 hasRelatedWork W2794162533 @default.
- W2277882234 hasRelatedWork W2883175830 @default.
- W2277882234 hasRelatedWork W2889439318 @default.
- W2277882234 hasRelatedWork W2919187205 @default.
- W2277882234 hasRelatedWork W2951370624 @default.
- W2277882234 hasRelatedWork W2986303961 @default.
- W2277882234 hasRelatedWork W3000862037 @default.
- W2277882234 hasRelatedWork W3174336160 @default.
- W2277882234 hasRelatedWork W3180822706 @default.
- W2277882234 isParatext "false" @default.
- W2277882234 isRetracted "false" @default.
- W2277882234 magId "2277882234" @default.
- W2277882234 workType "article" @default.