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- W2278028451 abstract "Technetium 99 conjugated with methylene diphosphonate, which is an anti‑inflammatory drug, can inhibit macrophage infiltration and downregulate a number of proinflammatory cytokines, such as tumor necrosis factor‑α and interleukin‑1β. Recently, numerous studies have indicated that it could improve rheumatoid arthritis (RA) activity by upregulating the frequency of peripheral γδ T cells and cluster of differentiation CD4+CD25+Foxp3+ Tregs, affecting the serum cytokine environment, inhibiting osteoclast formation and reducing the concentrations of rheumatoid factor‑immunoglobulin M (IgM)/IgG/IgA. As well, it may have a therapeutic role for choroidal neovascularisation (CNV) and Graves' ophthalmopathy (GO). Therefore, it will be a valuable choice in the treatment of RA, CNV and GO." @default.
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- W2278028451 date "2016-02-23" @default.
- W2278028451 modified "2023-09-30" @default.
- W2278028451 title "99Tc-MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy" @default.
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- W2278028451 doi "https://doi.org/10.3892/br.2016.609" @default.
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