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• W2278108486 abstract "The mechanisms by which the glomerular filtration barrier prevents the loss of large macromolecules and simultaneously, maintains the filter remain poorly understood. Recent studies proposed that podocytes have an active role in both the endocytosis of filtered macromolecules and the maintenance of the filtration barrier. Deletion of a key endosomal trafficking regulator, the class 3 phosphatidylinositol (PtdIns) 3-kinase vacuolar protein sorting 34 (Vps34), in podocytes results in aberrant endosomal membrane morphology and podocyte dysfunction. We recently showed that the vacuolation phenotype in cultured Vps34–deficient podocytes is caused by the absence of a substrate for the Vps34 downstream effector PtdIns 3-phosphate 5-kinase (PIKfyve), which phosphorylates Vps34-generated PtdIns(3)P to produce PtdIns (3,5)P2. PIKfyve perturbation and PtdIns(3,5)P2 reduction result in massive membrane vacuolation along the endosomal system, but the cell-specific functions of PIKfyve in vivo remain unclear. We show here that the genetic deletion of PIKfyve in endocytically active proximal tubular cells resulted in the development of large cytoplasmic vacuoles caused by arrested endocytic traffic progression at a late-endosome stage. In contrast, deletion of PIKfyve in glomerular podocytes did not significantly alter the endosomal morphology, even in age 18-month-old mice. However, on culturing, the PIKfyve-deleted podocytes developed massive cytoplasmic vacuoles. In summary, these data suggest that glomerular podocytes and proximal tubules have different requirements for PIKfyve function, likely related to distinct in vivo needs for endocytic flux." @default.
• W2278108486 created "2016-06-24" @default.
• W2278108486 creator A5013461744 @default.
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• W2278108486 date "2016-01-29" @default.
• W2278108486 modified "2023-10-17" @default.
• W2278108486 title "Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells" @default.
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• W2278108486 cites W1810238655 @default.
• W2278108486 cites W1878213572 @default.
• W2278108486 cites W1972845034 @default.
• W2278108486 cites W1974146917 @default.
• W2278108486 cites W1977834451 @default.
• W2278108486 cites W1978746677 @default.
• W2278108486 cites W1981817858 @default.
• W2278108486 cites W1983312443 @default.
• W2278108486 cites W1989283034 @default.
• W2278108486 cites W1991084644 @default.
• W2278108486 cites W1994729697 @default.
• W2278108486 cites W1996584317 @default.
• W2278108486 cites W1997791761 @default.
• W2278108486 cites W1998399313 @default.
• W2278108486 cites W2001902542 @default.
• W2278108486 cites W2003698382 @default.
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• W2278108486 cites W2012375411 @default.
• W2278108486 cites W2014375034 @default.
• W2278108486 cites W2016847093 @default.
• W2278108486 cites W2018046158 @default.
• W2278108486 cites W2022857776 @default.
• W2278108486 cites W2023410461 @default.
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• W2278108486 cites W2026376858 @default.
• W2278108486 cites W2027266132 @default.
• W2278108486 cites W2027474840 @default.
• W2278108486 cites W2030721984 @default.
• W2278108486 cites W2035810126 @default.
• W2278108486 cites W2037801572 @default.
• W2278108486 cites W2040375956 @default.
• W2278108486 cites W2049848256 @default.
• W2278108486 cites W2051011639 @default.
• W2278108486 cites W2053091007 @default.
• W2278108486 cites W2055136539 @default.
• W2278108486 cites W2057370954 @default.
• W2278108486 cites W2059605722 @default.
• W2278108486 cites W2064746187 @default.
• W2278108486 cites W2068335053 @default.
• W2278108486 cites W2071843728 @default.
• W2278108486 cites W2072204570 @default.
• W2278108486 cites W2072317853 @default.
• W2278108486 cites W2072850025 @default.
• W2278108486 cites W2073038040 @default.
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• W2278108486 cites W2083423972 @default.
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• W2278108486 cites W2120640283 @default.
• W2278108486 cites W2121539092 @default.
• W2278108486 cites W2121709524 @default.
• W2278108486 cites W2123507741 @default.
• W2278108486 cites W2124410251 @default.
• W2278108486 cites W2127006232 @default.
• W2278108486 cites W2127429861 @default.
• W2278108486 cites W2127516219 @default.
• W2278108486 cites W2132619856 @default.
• W2278108486 cites W2134918940 @default.
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• W2278108486 doi "https://doi.org/10.1681/asn.2015050555" @default.
• W2278108486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5004647" @default.
• W2278108486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26825532" @default.
• W2278108486 hasPublicationYear "2016" @default.
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