Matches in SemOpenAlex for { <https://semopenalex.org/work/W2278132649> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2278132649 abstract "<p>Tenosynovial giant cell tumors (TGCTs) are rare tumors, which are primarily treated via surgery with a low likelihood of metastasis. Although wide excision is an excellent choice for local control, tumors located within or close to major joints, along with the benign nature of the disease, make such resection impractical. An increase in local recurrences and the need for multiple surgical procedures promoted the interest in targeted-therapies for this disease. TGCTs contain a mixture of giant cells, mononuclear cells and inflammatory cells, with clonal cytogenetic abnormalities through rearrangements involving 1p11–13. Colony stimulating factor (<em>CSF1</em>) gene encodes for the ligand of CSF1 receptor (CSF1R). The <em>CSF1</em> gene is located at the chromosome 1p13 breakpoint and is found to be translocated in 63%–77% of patients with TGCTs. Selective CSF1R inhibitors yield high response rate and disease control, demonstrating the integration of a new drug development technology that could revolutionize treatment outcomes. </p>" @default.
- W2278132649 created "2016-06-24" @default.
- W2278132649 creator A5008127425 @default.
- W2278132649 date "2016-01-22" @default.
- W2278132649 modified "2023-10-03" @default.
- W2278132649 title "Tenosynovial Giant Cell Tumor: Better molecular understanding revolutionizes treatment outcome" @default.
- W2278132649 cites W1577003571 @default.
- W2278132649 cites W167956279 @default.
- W2278132649 cites W1931547192 @default.
- W2278132649 cites W1987315579 @default.
- W2278132649 cites W2015161575 @default.
- W2278132649 cites W2034034179 @default.
- W2278132649 cites W2052870379 @default.
- W2278132649 cites W2095744864 @default.
- W2278132649 cites W2102932257 @default.
- W2278132649 cites W2156758289 @default.
- W2278132649 cites W2266154765 @default.
- W2278132649 cites W2520361445 @default.
- W2278132649 cites W3158281136 @default.
- W2278132649 cites W982662479 @default.
- W2278132649 doi "https://doi.org/10.18282/amor.v2.i1.48" @default.
- W2278132649 hasPublicationYear "2016" @default.
- W2278132649 type Work @default.
- W2278132649 sameAs 2278132649 @default.
- W2278132649 citedByCount "0" @default.
- W2278132649 crossrefType "journal-article" @default.
- W2278132649 hasAuthorship W2278132649A5008127425 @default.
- W2278132649 hasBestOaLocation W22781326491 @default.
- W2278132649 hasConcept C142724271 @default.
- W2278132649 hasConcept C1491633281 @default.
- W2278132649 hasConcept C2779134260 @default.
- W2278132649 hasConcept C2908810772 @default.
- W2278132649 hasConcept C502942594 @default.
- W2278132649 hasConcept C54355233 @default.
- W2278132649 hasConcept C71924100 @default.
- W2278132649 hasConcept C77076574 @default.
- W2278132649 hasConcept C86803240 @default.
- W2278132649 hasConceptScore W2278132649C142724271 @default.
- W2278132649 hasConceptScore W2278132649C1491633281 @default.
- W2278132649 hasConceptScore W2278132649C2779134260 @default.
- W2278132649 hasConceptScore W2278132649C2908810772 @default.
- W2278132649 hasConceptScore W2278132649C502942594 @default.
- W2278132649 hasConceptScore W2278132649C54355233 @default.
- W2278132649 hasConceptScore W2278132649C71924100 @default.
- W2278132649 hasConceptScore W2278132649C77076574 @default.
- W2278132649 hasConceptScore W2278132649C86803240 @default.
- W2278132649 hasLocation W22781326491 @default.
- W2278132649 hasOpenAccess W2278132649 @default.
- W2278132649 hasPrimaryLocation W22781326491 @default.
- W2278132649 hasRelatedWork W108226853 @default.
- W2278132649 hasRelatedWork W1541563138 @default.
- W2278132649 hasRelatedWork W1929509244 @default.
- W2278132649 hasRelatedWork W1972940331 @default.
- W2278132649 hasRelatedWork W1975763635 @default.
- W2278132649 hasRelatedWork W2018586278 @default.
- W2278132649 hasRelatedWork W2045715105 @default.
- W2278132649 hasRelatedWork W2046479574 @default.
- W2278132649 hasRelatedWork W2077813502 @default.
- W2278132649 hasRelatedWork W2086612689 @default.
- W2278132649 hasRelatedWork W2092388888 @default.
- W2278132649 hasRelatedWork W2101912928 @default.
- W2278132649 hasRelatedWork W2104989233 @default.
- W2278132649 hasRelatedWork W2152302594 @default.
- W2278132649 hasRelatedWork W2413984899 @default.
- W2278132649 hasRelatedWork W3010687633 @default.
- W2278132649 hasRelatedWork W3034079650 @default.
- W2278132649 hasRelatedWork W3165245235 @default.
- W2278132649 hasRelatedWork W3199828952 @default.
- W2278132649 hasRelatedWork W328557071 @default.
- W2278132649 isParatext "false" @default.
- W2278132649 isRetracted "false" @default.
- W2278132649 magId "2278132649" @default.
- W2278132649 workType "article" @default.