FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2278246218> ?p ?o ?g. }

• W2278246218 endingPage "9" @default.
• W2278246218 startingPage "2095" @default.
• W2278246218 abstract "The authors model diabetes in rats, and inject the rats with Klotho gene. Then the levels of serum lipoprotein are tested, measuring the thickness of coronary artery intima and the ratio of intima and media to see whether Klotho gene has protective effect of coronary artery in diabetes rats.Extracting the Klotho gene from kidney tissue in the normal SD rats amplifies the target gene by PCR and uses adenovirus as carrier. Then SD rats were randomly divided into model group, control group and the treatment group for diabetes modeling. Transferred the Klotho gene into treatment group and blank adenovirus into control group by the experimenters. Nothing was done for model group. Rats were killed after a successful modeling in the twelfth week, then tested blood low-density lipoprotein, high density lipoprotein, and the coronary artery intima-media thickness. After doing these, intima-media thickness ratio was tested.The high density lipoprotein is 0.67 ± 0.06 mmol/L in treatment group, 0.48 ± 0.10 mmol/L in control group, 0.47 ± 0.10 mmol/L in model group. The treatment group, control group and model group respectively two independent sample tests. There is statistical significance between treatment group and the other group p<0.01 in treatment group. The low density lipoprotein is 0.44 ± 0.08 mmol/L in treatment group, 0.45 ± 0.10 mmol/L in control group, 0.44 ± 0.05 mmol/L in model group. Respectively two independent sample test show that there is no statistical significance between treatment group and the other group (p>0.05). Intima thickness is 1.74 ± 0.05 μm in treatment group, 2.23 ± 0.06 μm in control group, 2.15 ± 0.05 μm in model group. There is statistical significance between treatment group and the other group (p<0.01). The ratio of intima and media is 0.237 ± 0.097 in treatment group, 0.308 ± 0.023 in control group, 0.316 ± 0.037 in model group, and t test, there is statistical significance between treatment group and the other group (p<0.01).There is protective effect on coronary after Klotho gene was transferred into diabetic rats." @default.
• W2278246218 created "2016-06-24" @default.
• W2278246218 creator A5018788344 @default.
• W2278246218 creator A5028972793 @default.
• W2278246218 creator A5048638597 @default.
• W2278246218 creator A5060136784 @default.
• W2278246218 creator A5085789193 @default.
• W2278246218 date "2014-11-01" @default.
• W2278246218 modified "2023-09-23" @default.
• W2278246218 title "Study of klotho gene transfer for the protective effect of the coronary of diabetic rats." @default.
• W2278246218 cites W1992858960 @default.
• W2278246218 cites W2019973807 @default.
• W2278246218 cites W2043097275 @default.
• W2278246218 cites W2053369310 @default.
• W2278246218 cites W2056572369 @default.
• W2278246218 cites W2063996917 @default.
• W2278246218 cites W2094148720 @default.
• W2278246218 cites W2114360920 @default.
• W2278246218 cites W2164324917 @default.
• W2278246218 cites W2387466622 @default.
• W2278246218 cites W2444422131 @default.
• W2278246218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25410079" @default.
• W2278246218 hasPublicationYear "2014" @default.
• W2278246218 type Work @default.
• W2278246218 sameAs 2278246218 @default.
• W2278246218 citedByCount "0" @default.
• W2278246218 crossrefType "journal-article" @default.
• W2278246218 hasAuthorship W2278246218A5018788344 @default.
• W2278246218 hasAuthorship W2278246218A5028972793 @default.
• W2278246218 hasAuthorship W2278246218A5048638597 @default.
• W2278246218 hasAuthorship W2278246218A5060136784 @default.
• W2278246218 hasAuthorship W2278246218A5085789193 @default.
• W2278246218 hasConcept C126322002 @default.
• W2278246218 hasConcept C134018914 @default.
• W2278246218 hasConcept C2776820930 @default.
• W2278246218 hasConcept C2777178098 @default.
• W2278246218 hasConcept C2778163477 @default.
• W2278246218 hasConcept C2779620165 @default.
• W2278246218 hasConcept C2780072125 @default.
• W2278246218 hasConcept C2780091579 @default.
• W2278246218 hasConcept C2780541478 @default.
• W2278246218 hasConcept C2987047532 @default.
• W2278246218 hasConcept C555293320 @default.
• W2278246218 hasConcept C65409693 @default.
• W2278246218 hasConcept C71924100 @default.
• W2278246218 hasConcept C9832595 @default.
• W2278246218 hasConceptScore W2278246218C126322002 @default.
• W2278246218 hasConceptScore W2278246218C134018914 @default.
• W2278246218 hasConceptScore W2278246218C2776820930 @default.
• W2278246218 hasConceptScore W2278246218C2777178098 @default.
• W2278246218 hasConceptScore W2278246218C2778163477 @default.
• W2278246218 hasConceptScore W2278246218C2779620165 @default.
• W2278246218 hasConceptScore W2278246218C2780072125 @default.
• W2278246218 hasConceptScore W2278246218C2780091579 @default.
• W2278246218 hasConceptScore W2278246218C2780541478 @default.
• W2278246218 hasConceptScore W2278246218C2987047532 @default.
• W2278246218 hasConceptScore W2278246218C555293320 @default.
• W2278246218 hasConceptScore W2278246218C65409693 @default.
• W2278246218 hasConceptScore W2278246218C71924100 @default.
• W2278246218 hasConceptScore W2278246218C9832595 @default.
• W2278246218 hasIssue "6 Suppl" @default.
• W2278246218 hasLocation W22782462181 @default.
• W2278246218 hasOpenAccess W2278246218 @default.
• W2278246218 hasPrimaryLocation W22782462181 @default.
• W2278246218 hasRelatedWork W1976602105 @default.
• W2278246218 hasRelatedWork W2016752924 @default.
• W2278246218 hasRelatedWork W2030579633 @default.
• W2278246218 hasRelatedWork W2033921535 @default.
• W2278246218 hasRelatedWork W2117517864 @default.
• W2278246218 hasRelatedWork W2118738696 @default.
• W2278246218 hasRelatedWork W2160965297 @default.
• W2278246218 hasRelatedWork W2169343671 @default.
• W2278246218 hasRelatedWork W2413861530 @default.
• W2278246218 hasRelatedWork W4233524856 @default.
• W2278246218 hasVolume "27" @default.
• W2278246218 isParatext "false" @default.
• W2278246218 isRetracted "false" @default.
• W2278246218 magId "2278246218" @default.
• W2278246218 workType "article" @default.