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- W2278273924 abstract "The authors report the results of intravenous administration of the drug suramin (20 mg/kg body weight every 5 days for 35 days) to 5 Rwandese patients with acquired immunodeficiency syndrome (AIDS)-related complex. The patients symptoms before treatment included generalized lymphadenopathy chronic diarrhea and chronic arthralgias. The patients 3 women and 2 men all improved after the 1st injection of suramin and a weight gain was recored in 3 patients. Overall the patients tolerated the drug well. 2 patients reported transient fever and weakness after the 1st 2 injections but no proteinuria or hematologic disturbance developed during treatment. OKT4 lymphocytes and the OKT4/OKT8 ratio rose in 4 patients. Delayed hypersensitivity reaction to tuberculin and PHA was restored in the 3 patients tested. Suramin is judged to have had a positive effect on the short-term clinical and immunologic progress of 4 of the 5 patients evaluated. (The 5th patient whose condition was complicated by tuberculosis and malaria died during the study period.) Further research is urged to determine whether suramin can improve the prognosis of patients with full-blown AIDS." @default.
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- W2278273924 date "1985-01-01" @default.
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- W2278273924 title "Short-term results with suramin for AIDS-related conditions [letter]" @default.
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