FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2278282783> ?p ?o ?g. }

• W2278282783 endingPage "84" @default.
• W2278282783 startingPage "72" @default.
• W2278282783 abstract "Aging is a multifactorial process characterized by organ loss of function and degeneration, but the mechanisms involved remain elusive. We have shown recently that catecholamine metabolism drives the accumulation of mitochondrial DNA (mtDNA) deletions in dopaminergic cells, which likely contribute to their degeneration during aging. Here we investigated whether the well-documented degeneration and altered function of adrenals during aging is linked to catecholamine production in the medulla followed by accumulation of mtDNA deletions.We analyzed adrenal medullary and cortical samples of both murine and human origin covering a wide range of ages for mtDNA deletion content, mtDNA copy number, mitochondrial and cellular integrity as well as aging-related tissue changes such as fibrosis.Indeed, we demonstrate in mice and humans that the adrenal medulla accumulates a strikingly high amount of mtDNA deletions with age, causing mitochondrial dysfunction in the adrenal medulla, but also in the cortex, accompanied by apoptosis and, more importantly, by severe inflammation and remarkable fibrosis. Additionally, a concomitant and dramatic loss of medullary and cortical cells is observed in old animals.Our results show that accumulation of mtDNA deletions, and the ensuing mitochondrial dysfunction, is a hallmark of adrenal aging, further strengthening the hypothesis that catecholamine metabolism is detrimental to mtDNA integrity, mitochondrial function and cell survival. Moreover, the cell loss potentially induced by mitochondrial dysfunction could explain the decline in adrenal hormonal and steroidal secretion during aging." @default.
• W2278282783 created "2016-06-24" @default.
• W2278282783 creator A5016783058 @default.
• W2278282783 creator A5019658199 @default.
• W2278282783 creator A5022464786 @default.
• W2278282783 creator A5027713718 @default.
• W2278282783 creator A5077283122 @default.
• W2278282783 creator A5078316620 @default.
• W2278282783 date "2016-02-20" @default.
• W2278282783 modified "2023-10-18" @default.
• W2278282783 title "Catecholamine Metabolism Induces Mitochondrial DNA Deletions and Leads to Severe Adrenal Degeneration during Aging" @default.
• W2278282783 cites W1495866683 @default.
• W2278282783 cites W1596334946 @default.
• W2278282783 cites W1970587959 @default.
• W2278282783 cites W1980234111 @default.
• W2278282783 cites W1983737685 @default.
• W2278282783 cites W1991383343 @default.
• W2278282783 cites W1992805337 @default.
• W2278282783 cites W1997016042 @default.
• W2278282783 cites W1999339493 @default.
• W2278282783 cites W2011433072 @default.
• W2278282783 cites W2011805483 @default.
• W2278282783 cites W2015116743 @default.
• W2278282783 cites W2016228585 @default.
• W2278282783 cites W2017621114 @default.
• W2278282783 cites W2018982817 @default.
• W2278282783 cites W2025954751 @default.
• W2278282783 cites W2028696309 @default.
• W2278282783 cites W2033832481 @default.
• W2278282783 cites W2042734644 @default.
• W2278282783 cites W2044140189 @default.
• W2278282783 cites W2048421648 @default.
• W2278282783 cites W2049016912 @default.
• W2278282783 cites W2050303681 @default.
• W2278282783 cites W2051462224 @default.
• W2278282783 cites W2053619432 @default.
• W2278282783 cites W2054172399 @default.
• W2278282783 cites W2067814358 @default.
• W2278282783 cites W2077390242 @default.
• W2278282783 cites W2084621494 @default.
• W2278282783 cites W2088883478 @default.
• W2278282783 cites W2090366558 @default.
• W2278282783 cites W2091536676 @default.
• W2278282783 cites W2093277140 @default.
• W2278282783 cites W2094354899 @default.
• W2278282783 cites W2099788854 @default.
• W2278282783 cites W2102445981 @default.
• W2278282783 cites W2104198237 @default.
• W2278282783 cites W2106942479 @default.
• W2278282783 cites W2111477755 @default.
• W2278282783 cites W2120303646 @default.
• W2278282783 cites W2126072473 @default.
• W2278282783 cites W2132520721 @default.
• W2278282783 cites W2135317380 @default.
• W2278282783 cites W2136875709 @default.
• W2278282783 cites W2137639709 @default.
• W2278282783 cites W2141410612 @default.
• W2278282783 cites W2153460437 @default.
• W2278282783 cites W2159383423 @default.
• W2278282783 cites W2161693710 @default.
• W2278282783 cites W2166664098 @default.
• W2278282783 cites W4300939788 @default.
• W2278282783 doi "https://doi.org/10.1159/000444680" @default.
• W2278282783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26895241" @default.
• W2278282783 hasPublicationYear "2016" @default.
• W2278282783 type Work @default.
• W2278282783 sameAs 2278282783 @default.
• W2278282783 citedByCount "25" @default.
• W2278282783 countsByYear W22782827832016 @default.
• W2278282783 countsByYear W22782827832018 @default.
• W2278282783 countsByYear W22782827832019 @default.
• W2278282783 countsByYear W22782827832020 @default.
• W2278282783 countsByYear W22782827832021 @default.
• W2278282783 countsByYear W22782827832022 @default.
• W2278282783 countsByYear W22782827832023 @default.
• W2278282783 crossrefType "journal-article" @default.
• W2278282783 hasAuthorship W2278282783A5016783058 @default.
• W2278282783 hasAuthorship W2278282783A5019658199 @default.
• W2278282783 hasAuthorship W2278282783A5022464786 @default.
• W2278282783 hasAuthorship W2278282783A5027713718 @default.
• W2278282783 hasAuthorship W2278282783A5077283122 @default.
• W2278282783 hasAuthorship W2278282783A5078316620 @default.
• W2278282783 hasConcept C104317684 @default.
• W2278282783 hasConcept C126322002 @default.
• W2278282783 hasConcept C134018914 @default.
• W2278282783 hasConcept C24586158 @default.
• W2278282783 hasConcept C2775894120 @default.
• W2278282783 hasConcept C2777597313 @default.
• W2278282783 hasConcept C2777977426 @default.
• W2278282783 hasConcept C28859421 @default.
• W2278282783 hasConcept C54355233 @default.
• W2278282783 hasConcept C71924100 @default.
• W2278282783 hasConcept C86803240 @default.
• W2278282783 hasConcept C95444343 @default.
• W2278282783 hasConceptScore W2278282783C104317684 @default.
• W2278282783 hasConceptScore W2278282783C126322002 @default.
• W2278282783 hasConceptScore W2278282783C134018914 @default.
• W2278282783 hasConceptScore W2278282783C24586158 @default.

• next