FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2278341454> ?p ?o ?g. }

• W2278341454 endingPage "425" @default.
• W2278341454 startingPage "416" @default.
• W2278341454 abstract "Insufficient nitric oxide (NO) bioavailability plays an important role in endothelial dysfunction and arterial stiffening with aging. Supplementation with sodium nitrite, a precursor of NO, ameliorates age-related vascular endothelial dysfunction and arterial stiffness in mice, but effects on humans, including the metabolic pathways altered, are unknown. The purpose of this study was to determine the safety, feasibility, and efficacy of oral sodium nitrite supplementation for improving vascular function in middle-aged and older adults and to identify related circulating metabolites. Ten weeks of sodium nitrite (80 or 160 mg/day, capsules, TheraVasc; randomized, placebo control, double blind) increased plasma nitrite acutely (5- to 15-fold, P < 0.001 vs. placebo) and chronically (P < 0.10) and was well tolerated without symptomatic hypotension or clinically relevant elevations in blood methemoglobin. Endothelial function, measured by brachial artery flow-mediated dilation, increased 45-60% vs. baseline (P < 0.10) without changes in body mass or blood lipids. Measures of carotid artery elasticity (ultrasound and applanation tonometry) improved (decreased β-stiffness index, increased cross-sectional compliance, P < 0.05) without changes in brachial or carotid artery blood pressure. Aortic pulse wave velocity was unchanged. Nitrite-induced changes in vascular measures were significantly related to 11 plasma metabolites identified by untargeted analysis. Baseline abundance of multiple metabolites, including glycerophospholipids and fatty acyls, predicted vascular changes with nitrite. This study provides evidence that sodium nitrite supplementation is well tolerated, increases plasma nitrite concentrations, improves endothelial function, and lessens carotid artery stiffening in middle-aged and older adults, perhaps by altering multiple metabolic pathways, thereby warranting a larger clinical trial." @default.
• W2278341454 created "2016-06-24" @default.
• W2278341454 creator A5009451038 @default.
• W2278341454 creator A5015850816 @default.
• W2278341454 creator A5019907813 @default.
• W2278341454 creator A5026215348 @default.
• W2278341454 creator A5035175066 @default.
• W2278341454 creator A5042771710 @default.
• W2278341454 creator A5045803387 @default.
• W2278341454 creator A5049898685 @default.
• W2278341454 creator A5054813159 @default.
• W2278341454 creator A5058916727 @default.
• W2278341454 creator A5064713352 @default.
• W2278341454 creator A5070949985 @default.
• W2278341454 creator A5073380718 @default.
• W2278341454 creator A5084928760 @default.
• W2278341454 creator A5091792035 @default.
• W2278341454 date "2016-02-15" @default.
• W2278341454 modified "2023-10-14" @default.
• W2278341454 title "Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults" @default.
• W2278341454 cites W1559904992 @default.
• W2278341454 cites W1595822167 @default.
• W2278341454 cites W1623505186 @default.
• W2278341454 cites W1971447711 @default.
• W2278341454 cites W1974558588 @default.
• W2278341454 cites W1983986440 @default.
• W2278341454 cites W2006856548 @default.
• W2278341454 cites W2008003710 @default.
• W2278341454 cites W202179446 @default.
• W2278341454 cites W2034410132 @default.
• W2278341454 cites W2036689171 @default.
• W2278341454 cites W2037208677 @default.
• W2278341454 cites W2038686627 @default.
• W2278341454 cites W2045378100 @default.
• W2278341454 cites W2046186201 @default.
• W2278341454 cites W2056818529 @default.
• W2278341454 cites W2060667937 @default.
• W2278341454 cites W2066329782 @default.
• W2278341454 cites W2073027308 @default.
• W2278341454 cites W2073883908 @default.
• W2278341454 cites W2074088550 @default.
• W2278341454 cites W2098453482 @default.
• W2278341454 cites W2104801901 @default.
• W2278341454 cites W2108790161 @default.
• W2278341454 cites W2112943642 @default.
• W2278341454 cites W2116403540 @default.
• W2278341454 cites W2116514576 @default.
• W2278341454 cites W2120200123 @default.
• W2278341454 cites W2122091522 @default.
• W2278341454 cites W2122880159 @default.
• W2278341454 cites W2123422742 @default.
• W2278341454 cites W2130483595 @default.
• W2278341454 cites W2132772491 @default.
• W2278341454 cites W2136280068 @default.
• W2278341454 cites W2136329682 @default.
• W2278341454 cites W2136503561 @default.
• W2278341454 cites W2139500689 @default.
• W2278341454 cites W2149577614 @default.
• W2278341454 cites W2160234571 @default.
• W2278341454 cites W2161221966 @default.
• W2278341454 cites W2161841978 @default.
• W2278341454 cites W2163486802 @default.
• W2278341454 cites W2167376541 @default.
• W2278341454 cites W2168194587 @default.
• W2278341454 cites W2169784353 @default.
• W2278341454 cites W2170182466 @default.
• W2278341454 cites W2286008140 @default.
• W2278341454 cites W2607031541 @default.
• W2278341454 cites W4293084779 @default.
• W2278341454 cites W632359865 @default.
• W2278341454 doi "https://doi.org/10.1152/japplphysiol.00879.2015" @default.
• W2278341454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4754621" @default.
• W2278341454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26607249" @default.
• W2278341454 hasPublicationYear "2016" @default.
• W2278341454 type Work @default.
• W2278341454 sameAs 2278341454 @default.
• W2278341454 citedByCount "59" @default.
• W2278341454 countsByYear W22783414542015 @default.
• W2278341454 countsByYear W22783414542016 @default.
• W2278341454 countsByYear W22783414542017 @default.
• W2278341454 countsByYear W22783414542018 @default.
• W2278341454 countsByYear W22783414542019 @default.
• W2278341454 countsByYear W22783414542020 @default.
• W2278341454 countsByYear W22783414542021 @default.
• W2278341454 countsByYear W22783414542022 @default.
• W2278341454 countsByYear W22783414542023 @default.
• W2278341454 crossrefType "journal-article" @default.
• W2278341454 hasAuthorship W2278341454A5009451038 @default.
• W2278341454 hasAuthorship W2278341454A5015850816 @default.
• W2278341454 hasAuthorship W2278341454A5019907813 @default.
• W2278341454 hasAuthorship W2278341454A5026215348 @default.
• W2278341454 hasAuthorship W2278341454A5035175066 @default.
• W2278341454 hasAuthorship W2278341454A5042771710 @default.
• W2278341454 hasAuthorship W2278341454A5045803387 @default.
• W2278341454 hasAuthorship W2278341454A5049898685 @default.
• W2278341454 hasAuthorship W2278341454A5054813159 @default.
• W2278341454 hasAuthorship W2278341454A5058916727 @default.
• W2278341454 hasAuthorship W2278341454A5064713352 @default.

• next