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- W2278348613 abstract "ABSTRACT Purpose To explore the temporal relationship between brachial artery peak shear stress (Shear) and flow‐mediated dilation (FMD) in children and adults. Methods Shear and brachial artery diameter were tracked following reactive hyperemia in 122 children and 350 adults using sonographic imaging. Results Peak Shear, Shear area under the curve (Shear AUC ), and Peak FMD were significantly larger in children than in adults. The time to peak Shear (Shear TTP ) and time to peak FMD (FMD TTP ) were significantly lower in children, while there was no significant difference in time from Shear TTP to FMD TTP between children and adults. Conclusions Children have a lower shear stimulus and FMD response than adults, but the time interval separating these events is similar. These differences could be due to changes in vascular dynamics with age, including reduced smooth muscle cell responsiveness and other factors. Despite differences in timing, the interval from peak Shear to peak FMD was similar in children and adults. © 2015 Wiley Periodicals, Inc. J Clin Ultrasound 44 :182–187, 2016" @default.
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- W2278348613 date "2015-12-22" @default.
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- W2278348613 title "Peak shear and peak flow mediated dilation: a time-course relationship" @default.
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- W2278348613 doi "https://doi.org/10.1002/jcu.22324" @default.
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