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• W2278350076 abstract "Background: Althoughrecent meta-analyses indicates a consistent significant inverse relation ofserum 25 (OH) D and the prevalence of gestational diabetes mellitus (GDM), themechanism is unclear and conflicting opinions continue to be reported.Objectives: The objectives are: 1) comparison of vitamin D status in diabeticand non-diabetic pregnant women; 2) trying to determine the level of vitamin Dassociated with GDM, and its sensitivity and specificity; 3) determination ofthe relation of hypovitaminosis D with insulin resistance. Subjects andMethods: One hundred consecutive pregnant women (<28 weeks gestationalperiod) from the attendants of the out-patient clinic at our hospital werediagnosed for GDM by glucose tolerance test (GTT) (75 g 2 h). Among them, 40patients met the inclusion criteria for this study (group I). As a comparativegroup, another 40 pregnant ladies were included, 20 of them (group II) hadpre-gestational type II DM, and the other 20 (group III) had normal glucosetolerance (NGT) as a control. For all the participants, we estimated fastingblood glucose, fasting serum insulin, homeostasis model assessment of (HOMA-IRand HOMA-B), quantitative insulin sensitivity check index (QUICKI), and serum25-OH vit D. The ROC curve analysis was used to determine the optimal thresholdvalue of vit D in relation to DM. Results: Compared to the control group, thediabetic patients showed a statistically significant increase in the levels offasting glucose, 1-hour postprandial glucose, 2-hour post prandial glucose,fasting insulin, and HOMA-IR, (P=0.000 for all). None of the diabetic patientsshowed optimal vit D level. Vit D insuficiency (10 - 29 ng/ml) was found in32.5% of patients in group I, 55% in group II, and 50% in group III. Vit Ddeficiency (<10 ng/ml) was found in 67.5% of patients in group I, 45% ingroup II, and 0% in group III. Significant negative correlation was found forvit D with fasting insulin and FBS. The AUC for 25 OH vit D was 97%, CI was 95%and p-value was 0.0001. The sensitivity, specificity, and positive and negativepredictive values of 25 OH vit D in GDM versus control persons were 97%, 90%,95.1%, 94.7% respectively at a cut-off level <22 ng/ml. Conclusions:Although it might seem premature to draw a sharp relation betweenhypovitaminosis D and GDM, this study showed the importance of vit D in GDM,the need for supplementation below 22 ng/ml, and the role of hypovitaminosis Din increasing insulin resistance. Further randomized studies with vit Dsupplementation are recommended." @default.
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• W2278350076 date "2016-01-01" @default.
• W2278350076 modified "2023-09-26" @default.
• W2278350076 title "Vitamin D Deficiency and Gestational Diabetes Mellitus in Egyptian Women" @default.
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• W2278350076 doi "https://doi.org/10.4236/ojemd.2016.62015" @default.
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