Matches in SemOpenAlex for { <https://semopenalex.org/work/W2278369568> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2278369568 abstract "To examine the exact target cell and mechanism of action of epidermal growth factor (EGF) in the isolated cortical collecting duct from rabbit kidney, we compared electrical properties of collecting duct (CD) cells (principal cells) and intercalated (IC) cells in absence and presence of EGF at 10(-8) M. Differentiation of CD and IC cells was based on values of basolateral membrane voltage (Vb) and fractional apical membrane resistance (fRa). In CD cells, upon addition of EGF to bath, lumen-negative transepithelial voltage (VT) was decreased from -8.0 +/- 1.9 to -2.4 +/- 1.3 mV (n = 22, P less than 0.001), but Vb was little changed (from -85.1 +/- 2.8 to -83.1 +/- 2.7 mV, n = 19), indicating that EGF in bath mainly caused changes in apical membrane voltage. In addition, peritubular EGF increased transepithelial resistance (RT) from 132.9 +/- 15.8 to 153.8 +/- 18.4 omega.cm2 (n = 16, P less than 0.001) as well as fRa from 0.31 +/- 0.06 to 0.39 +/- 0.07 (n = 12, P less than 0.01). These actions of EGF were prevented by pretreatment with 50 microM luminal amiloride. Luminal EGF had no effects on VT, Vb, RT, or fRa of CD cells. In IC cells, upon addition of EGF to bath, neither Vb nor fRa was affected. From these results, we conclude that EGF acts on the CD cell at the basolateral border and inhibits mainly the amiloride-sensitive Na+ conductance in the apical membrane." @default.
- W2278369568 created "2016-06-24" @default.
- W2278369568 creator A5003711002 @default.
- W2278369568 creator A5004822786 @default.
- W2278369568 creator A5024921811 @default.
- W2278369568 creator A5042667479 @default.
- W2278369568 date "1991-02-01" @default.
- W2278369568 modified "2023-10-16" @default.
- W2278369568 title "Site and mechanism of action of epidermal growth factor in rabbit cortical collecting duct" @default.
- W2278369568 doi "https://doi.org/10.1152/ajprenal.1991.260.2.f163" @default.
- W2278369568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1996668" @default.
- W2278369568 hasPublicationYear "1991" @default.
- W2278369568 type Work @default.
- W2278369568 sameAs 2278369568 @default.
- W2278369568 citedByCount "22" @default.
- W2278369568 countsByYear W22783695682013 @default.
- W2278369568 countsByYear W22783695682015 @default.
- W2278369568 countsByYear W22783695682017 @default.
- W2278369568 crossrefType "journal-article" @default.
- W2278369568 hasAuthorship W2278369568A5003711002 @default.
- W2278369568 hasAuthorship W2278369568A5004822786 @default.
- W2278369568 hasAuthorship W2278369568A5024921811 @default.
- W2278369568 hasAuthorship W2278369568A5042667479 @default.
- W2278369568 hasConcept C12554922 @default.
- W2278369568 hasConcept C126322002 @default.
- W2278369568 hasConcept C134018914 @default.
- W2278369568 hasConcept C1491633281 @default.
- W2278369568 hasConcept C170493617 @default.
- W2278369568 hasConcept C178790620 @default.
- W2278369568 hasConcept C185592680 @default.
- W2278369568 hasConcept C2776362946 @default.
- W2278369568 hasConcept C2779608910 @default.
- W2278369568 hasConcept C2780091579 @default.
- W2278369568 hasConcept C2910744950 @default.
- W2278369568 hasConcept C3018436504 @default.
- W2278369568 hasConcept C39587587 @default.
- W2278369568 hasConcept C41625074 @default.
- W2278369568 hasConcept C537181965 @default.
- W2278369568 hasConcept C55493867 @default.
- W2278369568 hasConcept C71924100 @default.
- W2278369568 hasConcept C86803240 @default.
- W2278369568 hasConceptScore W2278369568C12554922 @default.
- W2278369568 hasConceptScore W2278369568C126322002 @default.
- W2278369568 hasConceptScore W2278369568C134018914 @default.
- W2278369568 hasConceptScore W2278369568C1491633281 @default.
- W2278369568 hasConceptScore W2278369568C170493617 @default.
- W2278369568 hasConceptScore W2278369568C178790620 @default.
- W2278369568 hasConceptScore W2278369568C185592680 @default.
- W2278369568 hasConceptScore W2278369568C2776362946 @default.
- W2278369568 hasConceptScore W2278369568C2779608910 @default.
- W2278369568 hasConceptScore W2278369568C2780091579 @default.
- W2278369568 hasConceptScore W2278369568C2910744950 @default.
- W2278369568 hasConceptScore W2278369568C3018436504 @default.
- W2278369568 hasConceptScore W2278369568C39587587 @default.
- W2278369568 hasConceptScore W2278369568C41625074 @default.
- W2278369568 hasConceptScore W2278369568C537181965 @default.
- W2278369568 hasConceptScore W2278369568C55493867 @default.
- W2278369568 hasConceptScore W2278369568C71924100 @default.
- W2278369568 hasConceptScore W2278369568C86803240 @default.
- W2278369568 hasLocation W22783695681 @default.
- W2278369568 hasLocation W22783695682 @default.
- W2278369568 hasOpenAccess W2278369568 @default.
- W2278369568 hasPrimaryLocation W22783695681 @default.
- W2278369568 hasRelatedWork W1515485341 @default.
- W2278369568 hasRelatedWork W1984123646 @default.
- W2278369568 hasRelatedWork W1984920038 @default.
- W2278369568 hasRelatedWork W2004074137 @default.
- W2278369568 hasRelatedWork W2041692611 @default.
- W2278369568 hasRelatedWork W2071061027 @default.
- W2278369568 hasRelatedWork W2085758110 @default.
- W2278369568 hasRelatedWork W2134163303 @default.
- W2278369568 hasRelatedWork W2278369568 @default.
- W2278369568 hasRelatedWork W4233755083 @default.
- W2278369568 isParatext "false" @default.
- W2278369568 isRetracted "false" @default.
- W2278369568 magId "2278369568" @default.
- W2278369568 workType "article" @default.