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- W2278424154 abstract "In the present investigation, a series ofnovel 3-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)indolin-2-one was synthesized by the Claisen-Schmidt condensation of indolin-2-one with substituted diaryl formylpyrazoles using alcoholic sodium hydroxide. The chemical structures of the newly synthesized compounds were characterized by IR, 1HNMR, and mass spectroscopy. The title compounds were evaluated for qualitative (zone of inhibition) and quantitative antibacterial activity (MIC) by agar diffusion and broth microdilution MIC (minimum inhibitory concentration) methods, respectively against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae. All the synthesized compounds were found active against Gram-positive bacteria, while showed very weak activity against Gram-negative bacteria. Docking study was performed to check interaction of synthesized compounds with the target DNA gyrase." @default.
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- W2278424154 date "2014-01-01" @default.
- W2278424154 modified "2023-10-17" @default.
- W2278424154 title "Design, Synthesis, Docking Study & Antibacterial Evaluation of 1,3- Diarylpyrazolyl Substituted Indolin-2-ones" @default.
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- W2278424154 doi "https://doi.org/10.35652/igjps.2014.117" @default.
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