Matches in SemOpenAlex for { <https://semopenalex.org/work/W2278441567> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2278441567 endingPage "108" @default.
- W2278441567 startingPage "102" @default.
- W2278441567 abstract "Background : Longitudinal bone growth is dependent on the state of the chondrocytes and the extracellular matrix of the growth plate. Hypervitaminosis A is known to result in limb shortening in several models, this anomaly has been related to the early closure of the epiphyseal plate. The specific contribution of the different chondrocyte types and the growth plates are not fully understood. The time specific response of chondrocyte might further unlock the mystery surrounding the teratogenic effect of Hypervitaminosis A on longitudinal bone growth. Objective : To evaluate the morphological response of the chondrocytes in the different zones of the growth plates following intrauterine hypervitaminosis A exposure at different periods of gestation. Methods: 18 time m ated adult wistar rats were divided into 3 groups. Groups A and B were administered 100,000IU of vitamin A in the 1st and 3rd trimester of gestation, while Group C served as control. Rat pups were examined after delivery and the humerus was processed histologically. The proximal and distal growth plates were examined and findings were noted. Result: In the proximal growth plate, the 1st trimester group showed smaller hypertrophic chondrocytes and a reduction in the height of the hypertrophic zone. Proliferating zone height was increased and columnar arrangement of chondrocyte was intact. In the 3rd trimester group, the height of the proliferating zone was reduced alongside disruption of the columnar arrangement of chondrocytes in the proliferating and hypertrophic zones. The distal growth plate revealed minimal differences between the chondrocytes of the different zones. Conclusion: The limb shortening effect of intrauterine hypervitaminosis A involve the hypertrophic and proliferating chondrocytes of the proximal growth plate. A reduction in the size of the hypertrophic chondrocytes in the 1st trimester and disruption of the columnar arrangement of the chondrocyte in the 3rd trimester are the main contributors to the limb shortening effect of intrauterine hypervitaminosis A on the rat forelimb. Keywords: Chondrocytes, Hypertrophic, Proliferating, Hypervitaminosis A, Growth plate." @default.
- W2278441567 created "2016-06-24" @default.
- W2278441567 creator A5010948847 @default.
- W2278441567 creator A5058216523 @default.
- W2278441567 date "2012-01-01" @default.
- W2278441567 modified "2023-09-26" @default.
- W2278441567 title "Growth Plate Chondrocytes' Morphology and Intrauterine Hypervitaminosis A in Newborn Rats" @default.
- W2278441567 cites W115923606 @default.
- W2278441567 cites W120611686 @default.
- W2278441567 cites W1588947851 @default.
- W2278441567 cites W1981797382 @default.
- W2278441567 cites W2012185862 @default.
- W2278441567 cites W2017899161 @default.
- W2278441567 cites W2027834875 @default.
- W2278441567 cites W2051471858 @default.
- W2278441567 cites W2057050837 @default.
- W2278441567 cites W2068069263 @default.
- W2278441567 cites W2083197990 @default.
- W2278441567 cites W2084111060 @default.
- W2278441567 cites W2103785439 @default.
- W2278441567 cites W2155493020 @default.
- W2278441567 cites W2437579198 @default.
- W2278441567 cites W27984251 @default.
- W2278441567 hasPublicationYear "2012" @default.
- W2278441567 type Work @default.
- W2278441567 sameAs 2278441567 @default.
- W2278441567 citedByCount "0" @default.
- W2278441567 crossrefType "journal-article" @default.
- W2278441567 hasAuthorship W2278441567A5010948847 @default.
- W2278441567 hasAuthorship W2278441567A5058216523 @default.
- W2278441567 hasConcept C105702510 @default.
- W2278441567 hasConcept C126322002 @default.
- W2278441567 hasConcept C134018914 @default.
- W2278441567 hasConcept C16685009 @default.
- W2278441567 hasConcept C189165786 @default.
- W2278441567 hasConcept C2776940978 @default.
- W2278441567 hasConcept C2778605803 @default.
- W2278441567 hasConcept C2778930362 @default.
- W2278441567 hasConcept C2779234561 @default.
- W2278441567 hasConcept C2779573558 @default.
- W2278441567 hasConcept C2780550940 @default.
- W2278441567 hasConcept C2781403057 @default.
- W2278441567 hasConcept C46973012 @default.
- W2278441567 hasConcept C54355233 @default.
- W2278441567 hasConcept C71924100 @default.
- W2278441567 hasConcept C86803240 @default.
- W2278441567 hasConcept C95444343 @default.
- W2278441567 hasConceptScore W2278441567C105702510 @default.
- W2278441567 hasConceptScore W2278441567C126322002 @default.
- W2278441567 hasConceptScore W2278441567C134018914 @default.
- W2278441567 hasConceptScore W2278441567C16685009 @default.
- W2278441567 hasConceptScore W2278441567C189165786 @default.
- W2278441567 hasConceptScore W2278441567C2776940978 @default.
- W2278441567 hasConceptScore W2278441567C2778605803 @default.
- W2278441567 hasConceptScore W2278441567C2778930362 @default.
- W2278441567 hasConceptScore W2278441567C2779234561 @default.
- W2278441567 hasConceptScore W2278441567C2779573558 @default.
- W2278441567 hasConceptScore W2278441567C2780550940 @default.
- W2278441567 hasConceptScore W2278441567C2781403057 @default.
- W2278441567 hasConceptScore W2278441567C46973012 @default.
- W2278441567 hasConceptScore W2278441567C54355233 @default.
- W2278441567 hasConceptScore W2278441567C71924100 @default.
- W2278441567 hasConceptScore W2278441567C86803240 @default.
- W2278441567 hasConceptScore W2278441567C95444343 @default.
- W2278441567 hasIssue "2" @default.
- W2278441567 hasLocation W22784415671 @default.
- W2278441567 hasOpenAccess W2278441567 @default.
- W2278441567 hasPrimaryLocation W22784415671 @default.
- W2278441567 hasRelatedWork W1964608315 @default.
- W2278441567 hasRelatedWork W1970801522 @default.
- W2278441567 hasRelatedWork W1973456619 @default.
- W2278441567 hasRelatedWork W1978310843 @default.
- W2278441567 hasRelatedWork W1988508511 @default.
- W2278441567 hasRelatedWork W1989962461 @default.
- W2278441567 hasRelatedWork W1991424506 @default.
- W2278441567 hasRelatedWork W2013870589 @default.
- W2278441567 hasRelatedWork W2039305820 @default.
- W2278441567 hasRelatedWork W2055682053 @default.
- W2278441567 hasRelatedWork W2056660225 @default.
- W2278441567 hasRelatedWork W2068851063 @default.
- W2278441567 hasRelatedWork W2094858816 @default.
- W2278441567 hasRelatedWork W2115565511 @default.
- W2278441567 hasRelatedWork W2133545343 @default.
- W2278441567 hasRelatedWork W2161969451 @default.
- W2278441567 hasRelatedWork W2231935339 @default.
- W2278441567 hasRelatedWork W2402616908 @default.
- W2278441567 hasRelatedWork W3030829274 @default.
- W2278441567 hasRelatedWork W2210989456 @default.
- W2278441567 hasVolume "11" @default.
- W2278441567 isParatext "false" @default.
- W2278441567 isRetracted "false" @default.
- W2278441567 magId "2278441567" @default.
- W2278441567 workType "article" @default.