Matches in SemOpenAlex for { <https://semopenalex.org/work/W2278747455> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2278747455 endingPage "8532" @default.
- W2278747455 startingPage "8532" @default.
- W2278747455 abstract "8532 Background: Hypothyroidism in pediatric Hodgkin's disease (HD) survivors is reported due to neck irradiation (RT). An effect of chemotherapy remains controversial. Methods: Records of 467 newly diagnosed HD patients treated on different regimens between 1979 and 2002 were reviewed. Radiation dose to the neck and clinical features were recorded. Hypothyroidism was defined as a TSH > 4.7 or need for thyroxine therapy. The cumulative incidence of hypothyroidism was calculated using SAS version 8.2 and treating relapse, death, or second cancer as competing risks. Results: Of 457 evaluable patients, 261 (57%) were male, 378 (83%) white; median age was 15.2 years (range 3 –21.7) and median time of thyroid follow up was 4.5 years (range 0.1 to 22.3). Treatment regimens used during this period were COPP, COPP/ABVD, VAMP, VEPA, VAMP/COP or Stanford V combined with RT or RT alone in selected patients with localized disease. The Table shows the cumulative incidence of hypothyroidism at 5 and 10 years according to the RT dose given. Patients in Group1 had no RT, a 7% incidence of hypothyroidism, and served as the reference group. Comparison of Group3 and Group4 shows a significant difference in cumulative incidence of hypothyroidism (p=0.004). Age at treatment was not a risk factor for developing hypothyroidism. The relative risk for females compared to males of developing hypothyroidism was 1.6 (p=0.0002) while the relative risk for blacks of developing hypothyroidism was 0.36 (p=0.0015) compared to non-blacks.Conclusions: Chemotherapy added to moderate (21–26.9Gy) dose RT, resulted in a higher incidence of hypothyroidism than high dose RT (>27Gy) alone. Table: Hypothyroidism Cumulative Incidence according to Radiation Dose / Chemotherapy No significant financial relationships to disclose." @default.
- W2278747455 created "2016-06-24" @default.
- W2278747455 creator A5011622752 @default.
- W2278747455 creator A5014617396 @default.
- W2278747455 creator A5019058700 @default.
- W2278747455 creator A5033944275 @default.
- W2278747455 creator A5048122275 @default.
- W2278747455 creator A5089743648 @default.
- W2278747455 date "2004-07-15" @default.
- W2278747455 modified "2023-09-26" @default.
- W2278747455 title "Hypothyroidism secondary to radiation and chemotherapy in pediatric Hodgkin's Disease" @default.
- W2278747455 doi "https://doi.org/10.1200/jco.2004.22.90140.8532" @default.
- W2278747455 hasPublicationYear "2004" @default.
- W2278747455 type Work @default.
- W2278747455 sameAs 2278747455 @default.
- W2278747455 citedByCount "0" @default.
- W2278747455 crossrefType "journal-article" @default.
- W2278747455 hasAuthorship W2278747455A5011622752 @default.
- W2278747455 hasAuthorship W2278747455A5014617396 @default.
- W2278747455 hasAuthorship W2278747455A5019058700 @default.
- W2278747455 hasAuthorship W2278747455A5033944275 @default.
- W2278747455 hasAuthorship W2278747455A5048122275 @default.
- W2278747455 hasAuthorship W2278747455A5089743648 @default.
- W2278747455 hasConcept C120665830 @default.
- W2278747455 hasConcept C121332964 @default.
- W2278747455 hasConcept C126322002 @default.
- W2278747455 hasConcept C141071460 @default.
- W2278747455 hasConcept C151032500 @default.
- W2278747455 hasConcept C181199279 @default.
- W2278747455 hasConcept C185592680 @default.
- W2278747455 hasConcept C187212893 @default.
- W2278747455 hasConcept C2776217839 @default.
- W2278747455 hasConcept C2776305933 @default.
- W2278747455 hasConcept C2776694085 @default.
- W2278747455 hasConcept C2776755627 @default.
- W2278747455 hasConcept C2779134260 @default.
- W2278747455 hasConcept C2779219270 @default.
- W2278747455 hasConcept C2779429289 @default.
- W2278747455 hasConcept C2779543040 @default.
- W2278747455 hasConcept C509974204 @default.
- W2278747455 hasConcept C55493867 @default.
- W2278747455 hasConcept C61511704 @default.
- W2278747455 hasConcept C71924100 @default.
- W2278747455 hasConcept C72563966 @default.
- W2278747455 hasConcept C88879693 @default.
- W2278747455 hasConceptScore W2278747455C120665830 @default.
- W2278747455 hasConceptScore W2278747455C121332964 @default.
- W2278747455 hasConceptScore W2278747455C126322002 @default.
- W2278747455 hasConceptScore W2278747455C141071460 @default.
- W2278747455 hasConceptScore W2278747455C151032500 @default.
- W2278747455 hasConceptScore W2278747455C181199279 @default.
- W2278747455 hasConceptScore W2278747455C185592680 @default.
- W2278747455 hasConceptScore W2278747455C187212893 @default.
- W2278747455 hasConceptScore W2278747455C2776217839 @default.
- W2278747455 hasConceptScore W2278747455C2776305933 @default.
- W2278747455 hasConceptScore W2278747455C2776694085 @default.
- W2278747455 hasConceptScore W2278747455C2776755627 @default.
- W2278747455 hasConceptScore W2278747455C2779134260 @default.
- W2278747455 hasConceptScore W2278747455C2779219270 @default.
- W2278747455 hasConceptScore W2278747455C2779429289 @default.
- W2278747455 hasConceptScore W2278747455C2779543040 @default.
- W2278747455 hasConceptScore W2278747455C509974204 @default.
- W2278747455 hasConceptScore W2278747455C55493867 @default.
- W2278747455 hasConceptScore W2278747455C61511704 @default.
- W2278747455 hasConceptScore W2278747455C71924100 @default.
- W2278747455 hasConceptScore W2278747455C72563966 @default.
- W2278747455 hasConceptScore W2278747455C88879693 @default.
- W2278747455 hasIssue "14_suppl" @default.
- W2278747455 hasLocation W22787474551 @default.
- W2278747455 hasOpenAccess W2278747455 @default.
- W2278747455 hasPrimaryLocation W22787474551 @default.
- W2278747455 hasRelatedWork W111432004 @default.
- W2278747455 hasRelatedWork W1982962683 @default.
- W2278747455 hasRelatedWork W2040074407 @default.
- W2278747455 hasRelatedWork W2079852658 @default.
- W2278747455 hasRelatedWork W2361616148 @default.
- W2278747455 hasRelatedWork W2405509401 @default.
- W2278747455 hasRelatedWork W2414079943 @default.
- W2278747455 hasRelatedWork W2417555288 @default.
- W2278747455 hasRelatedWork W4244871296 @default.
- W2278747455 hasRelatedWork W4290436003 @default.
- W2278747455 hasVolume "22" @default.
- W2278747455 isParatext "false" @default.
- W2278747455 isRetracted "false" @default.
- W2278747455 magId "2278747455" @default.
- W2278747455 workType "article" @default.