FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2278778870> ?p ?o ?g. }

• W2278778870 abstract "The present work has been done in the protein NMR group from the Structural and Computational Biology at the IRB Barcelona, under the direction of Dr. Maria J. Macias. The group main interest is the structural determination of protein domains, in the study of their interactions and in the understanding of the mechanisms for their regulation. In particular, this work is focused in the structural study of FF domains. In our group, the study of FF domains began from the observation that these domains are often found in proteins that also contain WW domains, a small protein-protein interaction domain that has been, and continues to be the central research line of the group and that has been object of numerous and detailed studies. Conversely, FF domains have been recently identified and the structural and functional information available on them is, to date, limited. One of the reasons of the few studies reported for these domains could be consequence of their reduced presence in proteins. In fact, FF domains are only present in three protein families: the splicing factors FBP11, Prp40 and URN1, the transcription factor CA150 and a family of RhoGTPase regulators, the p190 RhoGAPs. In our group, the work with FF domains started with the solution of the three-dimensional structure of the first FF domain from yeast Prp40, which just represented the second solved structure for an FF domain. In the present work the aim has been to gain insight into FF domain knowledge, basically from a structural point of view, using nuclear magnetic resonance (NMR) as the principal methodology for the structural studies. This thesis has been divided in three parts, and in each of them we have work with FF domains from the different families mentioned above. The subject of study has been also slightly different in each part. In the first chapter, focused in FF domains present in Prp40 and URN1 splicing factors, the principal work consisted in the obtaining of novel three-dimensional structures for these domains by NMR. In contrast, in the second chapter the main interest was the study of the interaction of CA150 FF domains with their first described ligand, a doubly phosphorylated motif of the RNA polymerase II C-terminal domain (phospho-CTD). Finally, in the last part our efforts were focused in the study of the regulation of p190-A RhoGAP FF domains association with the general transcription factor TFII-I through phosphorylation on the first FF domain of p190-A RhoGAP." @default.
• W2278778870 created "2016-06-24" @default.
• W2278778870 creator A5072064689 @default.
• W2278778870 date "2009-09-10" @default.
• W2278778870 modified "2023-09-26" @default.
• W2278778870 title "STRUCTURAL STUDIES ON FF DOMAINS BY NMR SPECTROSCOPY" @default.
• W2278778870 cites W108705584 @default.
• W2278778870 cites W1472557532 @default.
• W2278778870 cites W1501210482 @default.
• W2278778870 cites W1504502326 @default.
• W2278778870 cites W1518071796 @default.
• W2278778870 cites W1522341432 @default.
• W2278778870 cites W1604959358 @default.
• W2278778870 cites W1605091261 @default.
• W2278778870 cites W1913395666 @default.
• W2278778870 cites W1969400514 @default.
• W2278778870 cites W1970933479 @default.
• W2278778870 cites W1975459052 @default.
• W2278778870 cites W1977990253 @default.
• W2278778870 cites W1978314322 @default.
• W2278778870 cites W1979765627 @default.
• W2278778870 cites W1982042047 @default.
• W2278778870 cites W1984491329 @default.
• W2278778870 cites W1985189873 @default.
• W2278778870 cites W1985475442 @default.
• W2278778870 cites W1988391179 @default.
• W2278778870 cites W1990516841 @default.
• W2278778870 cites W1994305152 @default.
• W2278778870 cites W1995017064 @default.
• W2278778870 cites W2000948557 @default.
• W2278778870 cites W2002195659 @default.
• W2278778870 cites W2004379046 @default.
• W2278778870 cites W2006715676 @default.
• W2278778870 cites W2009973817 @default.
• W2278778870 cites W2029582401 @default.
• W2278778870 cites W2031686407 @default.
• W2278778870 cites W2034699659 @default.
• W2278778870 cites W2035216772 @default.
• W2278778870 cites W2039752285 @default.
• W2278778870 cites W2041359531 @default.
• W2278778870 cites W2041483465 @default.
• W2278778870 cites W2042199411 @default.
• W2278778870 cites W2045959839 @default.
• W2278778870 cites W2047131796 @default.
• W2278778870 cites W2049387285 @default.
• W2278778870 cites W2049631853 @default.
• W2278778870 cites W2052606462 @default.
• W2278778870 cites W2052822885 @default.
• W2278778870 cites W2055043387 @default.
• W2278778870 cites W2055420034 @default.
• W2278778870 cites W2056123159 @default.
• W2278778870 cites W2063575573 @default.
• W2278778870 cites W2064973680 @default.
• W2278778870 cites W2066310852 @default.
• W2278778870 cites W2072257591 @default.
• W2278778870 cites W2072979040 @default.
• W2278778870 cites W2079156263 @default.
• W2278778870 cites W2081282343 @default.
• W2278778870 cites W2083409440 @default.
• W2278778870 cites W2085277871 @default.
• W2278778870 cites W2088604869 @default.
• W2278778870 cites W2091849418 @default.
• W2278778870 cites W2097382368 @default.
• W2278778870 cites W2097859995 @default.
• W2278778870 cites W2098357851 @default.
• W2278778870 cites W2102025585 @default.
• W2278778870 cites W2104403651 @default.
• W2278778870 cites W2107925055 @default.
• W2278778870 cites W2109150623 @default.
• W2278778870 cites W2109648066 @default.
• W2278778870 cites W2109939279 @default.
• W2278778870 cites W2112462872 @default.
• W2278778870 cites W2115050780 @default.
• W2278778870 cites W2115517429 @default.
• W2278778870 cites W2117103287 @default.
• W2278778870 cites W2121528529 @default.
• W2278778870 cites W2122719600 @default.
• W2278778870 cites W2134807132 @default.
• W2278778870 cites W2140173312 @default.
• W2278778870 cites W2140448223 @default.
• W2278778870 cites W2141218148 @default.
• W2278778870 cites W2147490120 @default.
• W2278778870 cites W2148847731 @default.
• W2278778870 cites W2150125913 @default.
• W2278778870 cites W2152326664 @default.
• W2278778870 cites W2152854378 @default.
• W2278778870 cites W2152858457 @default.
• W2278778870 cites W2153245381 @default.
• W2278778870 cites W2158263698 @default.
• W2278778870 cites W2162362489 @default.
• W2278778870 cites W2163901967 @default.
• W2278778870 cites W2167557755 @default.
• W2278778870 cites W2169821755 @default.
• W2278778870 cites W2169979079 @default.
• W2278778870 cites W2229752110 @default.
• W2278778870 cites W255996521 @default.
• W2278778870 cites W1752645701 @default.
• W2278778870 hasPublicationYear "2009" @default.
• W2278778870 type Work @default.
• W2278778870 sameAs 2278778870 @default.

• next