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• W2278820821 abstract "Receptors are the molecular targets through which drugs produce their beneficial effects in a disease state. Receptors location, in the cell membrane or within the cell, contributes for the understanding of the subsequent signalling events triggered by their activation. The subcellular localization and physiological functions of receptors are closely related and thus it is crucial to precisely determine the distribution of different molecules inside the intracellular structures. This is usually studied by fluorescence microscopy and posterior evaluation of the colocalization of the molecule of interest in a definite region in the cell. Laser Scanning Confocal Microscopy (LSCM) imaging is a powerful tool allowing to distinguish a variety of unexpected locations for receptors, manly in subcellular locations such as mitochondria, lysosomes, nuclei[1] turns crucial rethinking the current knowledge of the pharmacological role ascribed to receptors. Moreover, the use of fluorescent ligands in tissues will also be addressed since it allows a multidimensional analysis and provides new insights to receptor dynamics and intracellular traffic.[2] This chapter describes some of the the strengths, limitations and potentialities associated with receptors Laser Scanning Confocal Microscopy (LSCM) imaging, giving some practical examples concerning our current research line. Emphasis is placed on the importance of appropriate image acquisition guiding the reader through the basic and advanced knowledge of major quantitative image analysis approaches. Quantitative evaluation of receptors in tissues provides information about receptor over, subexpression or redistribution contributing for the understanding of the impairment/deregulation associated with receptors putative physiological and/or pathophysiological role." @default.
• W2278820821 created "2016-06-24" @default.
• W2278820821 creator A5052509099 @default.
• W2278820821 date "2014-11-20" @default.
• W2278820821 modified "2023-09-27" @default.
• W2278820821 title "Adenosine receptors in vascular sympathetic neurotransmission: The role of endothelium and of nitric oxide-mediated effects and their relation with hypertension" @default.
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