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• W227887930 abstract "Research Article16 December 1996free access Bax alpha perturbs T cell development and affects cell cycle entry of T cells. H. J. Brady H. J. Brady Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author G. Gil-Gómez G. Gil-Gómez Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author J. Kirberg J. Kirberg Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author A. J. Berns A. J. Berns Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author H. J. Brady H. J. Brady Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author G. Gil-Gómez G. Gil-Gómez Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author J. Kirberg J. Kirberg Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author A. J. Berns A. J. Berns Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author Author Information H. J. Brady1, G. Gil-Gómez1, J. Kirberg1 and A. J. Berns1 1Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. The EMBO Journal (1996)15:6991-7001https://doi.org/10.1002/j.1460-2075.1996.tb01091.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Bax alpha can heterodimerize with Bcl-2 and Bcl-X(L), countering their effects, as well as promoting apoptosis on overexpression. We show that bax alpha transgenic mice have greatly reduced numbers of mature T cells, which results from an impaired positive selection in the thymus. This perturbation in positive selection is accompanied by an increase in the number of cycling thymocytes. Further to this, mature T cells overexpressing Bax alpha have lower levels of p27Kip1 and enter S phase more rapidly in response to interleukin-2 stimulation than do control T cells, while the converse is true of bcl-2 transgenic T cells. These data indicate that apoptotic regulatory proteins can modulate the level of cell cycle-controlling proteins and thereby directly impact on the cell cycle. Previous ArticleNext Article Volume 15Issue 241 December 1996In this issue RelatedDetailsLoading ..." @default.
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• W227887930 title "Bax alpha perturbs T cell development and affects cell cycle entry of T cells." @default.
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• W227887930 doi "https://doi.org/10.1002/j.1460-2075.1996.tb01091.x" @default.
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