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• W2278898871 endingPage "1514" @default.
• W2278898871 startingPage "1504" @default.
• W2278898871 abstract "Th17 cells are characterized as preferential producer of interleukins including IL-17A, IL-17F, IL-21 and IL-22. Corresponding receptors of these cytokines are expressed on number of cell types found in the mucosa, including epithelial cells and fibroblasts which constitute the prime targets of the Th17-associated cytokines. Binding of IL-17 family members to their corresponding receptors lead to modulation of antimicrobial functions of target cells including alveolar epithelial cells. Stimulated alveolar epithelial cells produce antimicrobial peptides and are involved in granulepoesis, neutrophil recruitment and tissue repair. Mucosal immunity mediated by Th17 cells is protective against numerous pulmonary pathogens including extracellular bacterial and fungal pathogens. This review focuses on the protective role of Th17 cells during pulmonary infection, highlighting subset differentiation, effector cytokines production, followed by study of the binding of these cytokines to their corresponding receptors, the subsequent signaling pathway they engender and their effector role in host defense." @default.
• W2278898871 created "2016-06-24" @default.
• W2278898871 creator A5003642180 @default.
• W2278898871 creator A5008980676 @default.
• W2278898871 date "2016-03-01" @default.
• W2278898871 modified "2023-10-17" @default.
• W2278898871 title "Protective role of Th17 cells in pulmonary infection" @default.
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