FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2278900005> ?p ?o ?g. }

• W2278900005 endingPage "14309" @default.
• W2278900005 startingPage "14300" @default.
• W2278900005 abstract "// Xiaodong Gao 1,2 , Anwei Xue 1,2 , Yong Fang 1,2 , Ping Shu 1,2 , Jiaqian Ling 1,2 , Yingyong Hou 3 , Kuntang Shen 1,2 , Jing Qin 1,2 , Yihong Sun 1,2 and Xinyu Qin 1,2 1 Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China 2 Institute of General Surgery, Fudan University, Shanghai, China 3 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China Correspondence to: Kuntang Shen, email: // Yingyong Hou, email: // Keywords : gastrointestinal stromal tumor, KIT, RACK1, imatinib Received : November 04, 2015 Accepted : January 29, 2016 Published : February 16, 2016 Abstract Although treatment with imatinib, which inhibits KIT and PDGFR, controls advanced disease in about 80% of gastrointestinal stromal tumor (GIST) patients, resistance to imatinib often develops. RACK1 (Receptor for Activated C Kinase 1) is a ribosomal protein that contributes to tumor progression by affecting proliferation, apoptosis, angiogenesis, and migration. Here, we found that c-KIT binds to RACK1 and increases proteasome-mediated RACK1 degradation. Imatinib treatment inhibits c-KIT activity and prevents RACK1 degradation, and RACK1 is upregulated in imatinib-resistant GIST cells compared to non-resistant parental cells. Moreover, Erk and Akt signaling were reactivated by imatinib in resistant GIST cells. RACK1 functioned as a scaffold protein and mediated Erk and Akt reactivation after imatinib treatment, thereby promoting GIST cell survival even in the presence of imatinib. Combined inhibition of KIT and RACK1 inhibited growth in imatinib-resistant GIST cell lines and reduced tumor relapse in GIST xenografts. These findings provide new insight into the role of RACK1 in imatinib resistance in GIST." @default.
• W2278900005 created "2016-06-24" @default.
• W2278900005 creator A5018872547 @default.
• W2278900005 creator A5020089499 @default.
• W2278900005 creator A5040074001 @default.
• W2278900005 creator A5040730790 @default.
• W2278900005 creator A5047645204 @default.
• W2278900005 creator A5048456007 @default.
• W2278900005 creator A5050112627 @default.
• W2278900005 creator A5051946362 @default.
• W2278900005 creator A5071138441 @default.
• W2278900005 creator A5080648163 @default.
• W2278900005 date "2016-02-16" @default.
• W2278900005 modified "2023-10-12" @default.
• W2278900005 title "RACK1 overexpression is linked to acquired imatinib resistance in gastrointestinal stromal tumor" @default.
• W2278900005 cites W1883936019 @default.
• W2278900005 cites W1933891757 @default.
• W2278900005 cites W1965871143 @default.
• W2278900005 cites W1977789206 @default.
• W2278900005 cites W1984213115 @default.
• W2278900005 cites W1985850556 @default.
• W2278900005 cites W1990113824 @default.
• W2278900005 cites W2001967800 @default.
• W2278900005 cites W2015015957 @default.
• W2278900005 cites W2020774038 @default.
• W2278900005 cites W2022207031 @default.
• W2278900005 cites W2041255253 @default.
• W2278900005 cites W2057470956 @default.
• W2278900005 cites W2071746901 @default.
• W2278900005 cites W2073100248 @default.
• W2278900005 cites W2087875641 @default.
• W2278900005 cites W2098178673 @default.
• W2278900005 cites W2103304755 @default.
• W2278900005 cites W2110682589 @default.
• W2278900005 cites W2115504770 @default.
• W2278900005 cites W2118165245 @default.
• W2278900005 cites W2129029860 @default.
• W2278900005 cites W2129931005 @default.
• W2278900005 cites W2141787711 @default.
• W2278900005 cites W2155228605 @default.
• W2278900005 cites W2159360580 @default.
• W2278900005 cites W2160275193 @default.
• W2278900005 cites W2160332942 @default.
• W2278900005 cites W2171620774 @default.
• W2278900005 cites W2144486990 @default.
• W2278900005 doi "https://doi.org/10.18632/oncotarget.7426" @default.
• W2278900005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4924716" @default.
• W2278900005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26893362" @default.
• W2278900005 hasPublicationYear "2016" @default.
• W2278900005 type Work @default.
• W2278900005 sameAs 2278900005 @default.
• W2278900005 citedByCount "4" @default.
• W2278900005 countsByYear W22789000052017 @default.
• W2278900005 countsByYear W22789000052019 @default.
• W2278900005 countsByYear W22789000052023 @default.
• W2278900005 crossrefType "journal-article" @default.
• W2278900005 hasAuthorship W2278900005A5018872547 @default.
• W2278900005 hasAuthorship W2278900005A5020089499 @default.
• W2278900005 hasAuthorship W2278900005A5040074001 @default.
• W2278900005 hasAuthorship W2278900005A5040730790 @default.
• W2278900005 hasAuthorship W2278900005A5047645204 @default.
• W2278900005 hasAuthorship W2278900005A5048456007 @default.
• W2278900005 hasAuthorship W2278900005A5050112627 @default.
• W2278900005 hasAuthorship W2278900005A5051946362 @default.
• W2278900005 hasAuthorship W2278900005A5071138441 @default.
• W2278900005 hasAuthorship W2278900005A5080648163 @default.
• W2278900005 hasBestOaLocation W22789000051 @default.
• W2278900005 hasConcept C126322002 @default.
• W2278900005 hasConcept C16930146 @default.
• W2278900005 hasConcept C184235292 @default.
• W2278900005 hasConcept C2775922572 @default.
• W2278900005 hasConcept C2777007597 @default.
• W2278900005 hasConcept C2777583451 @default.
• W2278900005 hasConcept C2778729363 @default.
• W2278900005 hasConcept C2780394083 @default.
• W2278900005 hasConcept C3019892230 @default.
• W2278900005 hasConcept C502942594 @default.
• W2278900005 hasConcept C57074206 @default.
• W2278900005 hasConcept C62478195 @default.
• W2278900005 hasConcept C71924100 @default.
• W2278900005 hasConcept C75217442 @default.
• W2278900005 hasConcept C86803240 @default.
• W2278900005 hasConcept C95444343 @default.
• W2278900005 hasConceptScore W2278900005C126322002 @default.
• W2278900005 hasConceptScore W2278900005C16930146 @default.
• W2278900005 hasConceptScore W2278900005C184235292 @default.
• W2278900005 hasConceptScore W2278900005C2775922572 @default.
• W2278900005 hasConceptScore W2278900005C2777007597 @default.
• W2278900005 hasConceptScore W2278900005C2777583451 @default.
• W2278900005 hasConceptScore W2278900005C2778729363 @default.
• W2278900005 hasConceptScore W2278900005C2780394083 @default.
• W2278900005 hasConceptScore W2278900005C3019892230 @default.
• W2278900005 hasConceptScore W2278900005C502942594 @default.
• W2278900005 hasConceptScore W2278900005C57074206 @default.
• W2278900005 hasConceptScore W2278900005C62478195 @default.
• W2278900005 hasConceptScore W2278900005C71924100 @default.
• W2278900005 hasConceptScore W2278900005C75217442 @default.
• W2278900005 hasConceptScore W2278900005C86803240 @default.

• next