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- W2278903903 abstract "The aim of this study was to investigate the effect Sereny test caused by Candida albicans in experimental induced ulcer in rabbit.Corneal ulcer was induced by superficially inoculated with 100µl of C. albicans containing1.5×10 8 CFU and dropped on left eye with sterilized PBS was topically applied to right eye in 50 rabbits .These animals were divided equally into two groups .The first group with nontreated with cyclophosphamide andsecondgrouptreatedwith cyclophosphamide (immunosuppressed) Seven days later corneas photographed and animals killed . After sacrificing the corneas of animals underwent routine histopathological examination on the day 1 st , 3 rd ,7 th days after inoculation. Histological examination reveals that no significant changes were found in ocular tissues on the 1 st day of infection in two groups, Hyphae did not penetrate into the deep layers of the cornea in any of non treated cyclophosphamide group in the contrast of second group treated with cyclophosphamide ,also seen infiltration of inflammatory cells with complete destruction of retina .Experimental study of infection of Candida albicans in rabbits revealed a positivity for Sereny test and resulted in conjunctivitis, kerititis and finally retinitis . Histopathological changes were induced in ocular tissue associated with infiltration of polymorph nuclear cells in the infected eye by Candida albicans . under test ." @default.
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- W2278903903 date "2015-05-12" @default.
- W2278903903 modified "2023-09-27" @default.
- W2278903903 title "Study the pathogenesis of Candida albicans in animal model" @default.
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- W2278903903 doi "https://doi.org/10.6084/m9.figshare.1411041.v1" @default.
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