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• W2278966217 abstract "9659 Background:HRT and inadequate screening are proposed explanations for a recent increased incidence of tumors > 5 cm (CA Cancer J Clin 2003;53:342). Methods: Data from a large hospital tumor registry of women diagnosed 1980–2002 with unilateral tumors were evaluated for size, stage, histology, age and (2000–2) detection method. Univariate associations were explored and stepwise linear/logistic multivariate models constructed. Results: Of 4652 cases; 76% had adequate size data; missing data were associated with diagnosis before 1986 and stage IV disease. While women with more recent diagnoses were younger (p<.0001), the proportion < 40 years did not change (1980–89: 7.0%; 2000–2: 8.8%; p=.12). In the 1980's, later year of diagnosis correlated with decreasing tumor size (p=.012) and proportion > 5 cm (p=.036); after 1989, increasing patterns were seen (p=.027 and p=.0004). Tumor size for women age < 40 increased (mean 2.67 [1980–89] to 3.48 [2000–2] cm, p<.0001) while those 40–50 (2.38 to 2.37 cm, p<.0001) and > 50 (2.43 to 2.09 cm, p<.0001) exhibited decreases. Since 1980 increasing proportions > 5 cm were seen for women age < 40 (p = .0053) and 40–50 (p = .028) but not > 50 (p = .79); the proportion of tumors stage ≥ IIIA did not change for patients age < 40 (despite fewer stage IV cases), while decreases were seen for those 40–50 (p=.001) and > 50 (p<.0001). Continuous variables were positively (year, age2, year2) or negatively (age, age/year interaction) correlated with increasing proportions > 5cm/ ≥ stage IIIA in univariate/multivariate models. Since 2000, patient-detected tumors in those age < 40 were larger compared to self-detected tumors in older women (p=.01), but mammographically-detected tumors were of similar size in both age groups. Conclusions: After decreasing during the 1980's, tumor size/tumors > 5 cm have increased; this seems to be limited to premenopausal women, particularly age < 40. HRT is an unlikely explanation; others possibilities include earlier age at detection combined with less effective screening for younger women, and more diligent primary tumor measurements coinciding with fewer stage IV presentations. No significant financial relationships to disclose." @default.
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• W2278966217 date "2004-07-15" @default.
• W2278966217 modified "2023-09-25" @default.
• W2278966217 title "Is hormone-replacement therapy (HRT) a plausible explanation for the recent increase in large breast tumor incidence?" @default.
• W2278966217 doi "https://doi.org/10.1200/jco.2004.22.90140.9659" @default.
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