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- W2279007583 abstract "Type 2 diabetes (T2D) is growing faster in Africa than anywhere else, driven by the dual effects of genetic and environmental factors. We conducted a systematic review and meta-analyses of published studies on genetic markers of T2D in populations within Africa.Multiple databases were searched for studies of genetic variants associated with T2D in populations living in Africa. Studies reporting on the association of a genetic marker with T2D or indicators of glycaemia were included. Data were extracted on study design and characteristics, genetic determinants, effect estimates of associations with T2D.Overall, 100 polymorphisms in 57 genes have been investigated in relation with T2D in populations within Africa, in 60 studies. Almost all studies used the candidate gene approach, with >88% published during 2006-2014 and 70% (42/60) originating from Tunisia and Egypt. Polymorphisms in ACE, AGRP, eNOS, GSTP1, HSP70-2, MC4R, MTHFR, PHLPP, POL1, TCF7L2, and TNF-α gene were found to be associated with T2D, with overlapping effect on various cardiometabolic traits. The polymorphisms investigated in multiple studies mostly had consistent effects across studies, with only modest or no statistical heterogeneity. Effect sizes were modestly significant [e.g., odd ratio 1.49 (95%CI 1.33-1.66) for TCF7L2 (rs7903146)]. Underpowered genome-wide studies revealed no diabetes risk loci specific to African populations.Current evidence on the genetic markers of T2D in African populations mostly originate from North African countries, is overall scanty and largely insufficient to reliably inform the genetic architecture of T2D across Africa." @default.
- W2279007583 created "2016-06-24" @default.
- W2279007583 creator A5000185410 @default.
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- W2279007583 date "2016-04-01" @default.
- W2279007583 modified "2023-10-16" @default.
- W2279007583 title "Genetic risk of type 2 diabetes in populations of the African continent: A systematic review and meta-analyses" @default.
- W2279007583 cites W1780273339 @default.
- W2279007583 cites W1918314026 @default.
- W2279007583 cites W1968287221 @default.
- W2279007583 cites W1973858281 @default.
- W2279007583 cites W1977858765 @default.
- W2279007583 cites W1980424398 @default.
- W2279007583 cites W1984476659 @default.
- W2279007583 cites W1986560158 @default.
- W2279007583 cites W1988180850 @default.
- W2279007583 cites W1989227759 @default.
- W2279007583 cites W1990989969 @default.
- W2279007583 cites W1993074086 @default.
- W2279007583 cites W2002498121 @default.
- W2279007583 cites W2002732332 @default.
- W2279007583 cites W2004342374 @default.
- W2279007583 cites W2006143663 @default.
- W2279007583 cites W2006782044 @default.
- W2279007583 cites W2008205161 @default.
- W2279007583 cites W2017034963 @default.
- W2279007583 cites W2019020805 @default.
- W2279007583 cites W2021820187 @default.
- W2279007583 cites W2024888186 @default.
- W2279007583 cites W2025539853 @default.
- W2279007583 cites W2026824411 @default.
- W2279007583 cites W2027031624 @default.
- W2279007583 cites W2028834965 @default.
- W2279007583 cites W2036329920 @default.
- W2279007583 cites W2038868007 @default.
- W2279007583 cites W2038983924 @default.
- W2279007583 cites W2042588195 @default.
- W2279007583 cites W2042703969 @default.
- W2279007583 cites W2045017910 @default.
- W2279007583 cites W2052344684 @default.
- W2279007583 cites W2052638307 @default.
- W2279007583 cites W2055538648 @default.
- W2279007583 cites W2063297627 @default.
- W2279007583 cites W2065749951 @default.
- W2279007583 cites W2067483525 @default.
- W2279007583 cites W2068532940 @default.
- W2279007583 cites W2069776419 @default.
- W2279007583 cites W2072483459 @default.
- W2279007583 cites W2074470899 @default.
- W2279007583 cites W2076635489 @default.
- W2279007583 cites W2084405640 @default.
- W2279007583 cites W2086256328 @default.
- W2279007583 cites W2088397492 @default.
- W2279007583 cites W2089023778 @default.
- W2279007583 cites W2091717229 @default.
- W2279007583 cites W2092967794 @default.
- W2279007583 cites W2093082706 @default.
- W2279007583 cites W2093900806 @default.
- W2279007583 cites W2094249344 @default.
- W2279007583 cites W2096791516 @default.
- W2279007583 cites W2097561770 @default.
- W2279007583 cites W2097605596 @default.
- W2279007583 cites W2106279462 @default.
- W2279007583 cites W2108102133 @default.
- W2279007583 cites W2114328140 @default.
- W2279007583 cites W2114687295 @default.
- W2279007583 cites W2119605658 @default.
- W2279007583 cites W2120568579 @default.
- W2279007583 cites W2120736554 @default.
- W2279007583 cites W2125435699 @default.
- W2279007583 cites W2125850997 @default.
- W2279007583 cites W2126185323 @default.
- W2279007583 cites W2126257245 @default.
- W2279007583 cites W2126332239 @default.
- W2279007583 cites W2126490636 @default.
- W2279007583 cites W2126930838 @default.
- W2279007583 cites W2127738936 @default.
- W2279007583 cites W2129433078 @default.
- W2279007583 cites W2129549687 @default.
- W2279007583 cites W2134593690 @default.
- W2279007583 cites W2142872405 @default.
- W2279007583 cites W2145264359 @default.
- W2279007583 cites W2148749248 @default.
- W2279007583 cites W2148857774 @default.
- W2279007583 cites W2149365861 @default.
- W2279007583 cites W2155536385 @default.
- W2279007583 cites W2157823046 @default.
- W2279007583 cites W2166112123 @default.
- W2279007583 cites W2167417252 @default.
- W2279007583 cites W2167775693 @default.
- W2279007583 cites W2168652720 @default.