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- W2279050413 abstract "Withania somnifera Dunal (Solanaceae) is a plant commonly used in Ayurvedic medicine to treat several diseases [1]. Interestingly, Kulkarni and Ninan [2] demonstrated that, in mice chronically treated with morphine, a methanol extract of W. somnifera roots prevented the development of tolerance to the antinociceptive effect of morphine. These studies suggested a possible anti-nociceptive effect of W. somnifera. Using behavioral approaches we demonstrated for the first time the ability of a W. somnifera methanol extract (WSE) pre-treatment to prolong analgesia and to prevent the development of rebound hyperalgesia in mice treated with morphine [3]. Consequently, we examined the affinity of WSE and a soluble ethyl acetate fraction obtained from WSE towards opioid, cannabinoid, GABAergic and glutamatergic receptors using radioligand receptor binding assays. WSE exhibited the highest affinity for the GABAA receptors (Kì= 13 µg/mL) while the ethyl acetate fraction showed good binding affinity for the opioid and cannabinoid receptors (Kì= 12 – 44 µg/mL). From the active extracts four withanolides (withanolide A, withanone, 12-deoxywithastramonolide and withaferin A), four alkaloids (anaferine, (+)-sedridine, tropine, choline) along ferulic acid methyl ester have been isolated. Some compounds exhibited moderate binding affinity (Kì= 15 – 40 µM) for opioid and cannabinoids receptors." @default.
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- W2279050413 date "2015-11-25" @default.
- W2279050413 modified "2023-10-09" @default.
- W2279050413 title "Withanolides and alkaloids from Withania somnifera roots with binding affinity to opioid, cannabinoids and GABAergic receptors" @default.
- W2279050413 doi "https://doi.org/10.1055/s-0035-1565746" @default.
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