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- W2279052364 abstract "To investigate the stereoselective pharmacokinetic process of tetrahydropalmatine (THP) in rats.The concentrations of tetrahydropalmatine enantiomers in rat plasma were determined by coupled achiral and chiral HPLC method. The differences in plasma concentrations and pharmacokinetic parameters between the two enantiomers were compared by paired t-test.The plasma levels of l-THP were always higher than those of d-THP in eight rats. There was significant difference between the main pharmacokinetic parameters of the two enantiomers.Tetrahydropalmatine showed significant stereoselective pharmacokinetics in rats after an ig dose of the racemate." @default.
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- W2279052364 date "2005-08-01" @default.
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- W2279052364 title "[Stereoselective pharmacokinetics of tetrahydropalmatine in rats]." @default.
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