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- W2279088384 abstract "Significance Growing experimental evidence suggests that the pathological spreading of alpha-synuclein aggregates in Parkinson’s disease is mediated through a process of templated seeding whereby aggregates catalyze the conversion of soluble protein molecules into their aggregated forms. A molecular-level understanding of this process is still lacking. Here, we determine the concentrations and numbers of aggregates necessary for the effective seeding of alpha-synuclein, thus providing a quantitative framework to understand the conditions when its seeded propagation is favorable. We find that high concentrations of aggregates are needed for seeding yet that aggregates cause cytotoxicity at significantly lower concentrations. This suggests that templated seeding is unlikely to be the main mechanism of spreading in Parkinson’s disease but occurs together with oligomer-induced cellular stress." @default.
- W2279088384 created "2016-06-24" @default.
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- W2279088384 date "2016-02-16" @default.
- W2279088384 modified "2023-10-16" @default.
- W2279088384 title "Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading" @default.
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- W2279088384 doi "https://doi.org/10.1073/pnas.1524128113" @default.
- W2279088384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4780632" @default.
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