Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279106504> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2279106504 abstract "__Abstract__The evolution of complex nervous systems from simple sensory apparatusesin animals provides great advantages to these organisms. Not only does this facilitatetheir interactions with the outside world, but it also helps them to regulate homeostasis.Like all information transfer protocols, speed is a very important aspect of nerve impulsepropagation. Neurons themselves are capable of very fast nerve conduction velocities, butmyelination by glial cells gives a new meaning to the term conduction velocity as it cranksup the speed by two orders of magnitude. In the peripheral nerves of higher vertebrates,large calibre axons are myelinated by Schwann cells, whereas small calibre axons aresupported by non-myelinating Schwann cells. Development and myelination of peripheralnerves involves the intimate association of neurons and glia, and the molecular cross-talkbetween axons and Schwann cells. Whereas several mechanisms both in the extra- andintracellular environments have been studied extensively, many unknowns governing thedevelopment and myelination of the peripheral nervous system remain. The main aim ofthis thesis is to identify and characterize such mechanisms, and the molecules involved.Throughout this project, we have worked with Claw paw, Lgi4, and Adam22 mutant mice.These animals display similar limb abnormalities, and hypomyelinated peripheral nerves.Combined efforts from our lab and our collaborators enabled us to characterize severalaspects of these phenotypes, and to study the role of Lgi4 and Adam22 proteins." @default.
- W2279106504 created "2016-06-24" @default.
- W2279106504 creator A5049387464 @default.
- W2279106504 date "2009-11-11" @default.
- W2279106504 modified "2023-09-27" @default.
- W2279106504 title "From Lgi4 to Adam22: Novel Players in Peripheral Nervous System Development and Myelination" @default.
- W2279106504 cites W1756962622 @default.
- W2279106504 cites W1864472777 @default.
- W2279106504 cites W1967336797 @default.
- W2279106504 cites W1969180602 @default.
- W2279106504 cites W1983872098 @default.
- W2279106504 cites W1986361477 @default.
- W2279106504 cites W1987988481 @default.
- W2279106504 cites W1988665933 @default.
- W2279106504 cites W1992398154 @default.
- W2279106504 cites W1997044589 @default.
- W2279106504 cites W1999942847 @default.
- W2279106504 cites W2010257803 @default.
- W2279106504 cites W2012590368 @default.
- W2279106504 cites W2012896016 @default.
- W2279106504 cites W2018581402 @default.
- W2279106504 cites W2045834236 @default.
- W2279106504 cites W2064419492 @default.
- W2279106504 cites W2079967292 @default.
- W2279106504 cites W2090663837 @default.
- W2279106504 cites W2092322285 @default.
- W2279106504 cites W2102718676 @default.
- W2279106504 cites W2112204388 @default.
- W2279106504 cites W2117727028 @default.
- W2279106504 cites W2122912494 @default.
- W2279106504 cites W2126432980 @default.
- W2279106504 cites W2127170913 @default.
- W2279106504 cites W2128436211 @default.
- W2279106504 cites W2162672934 @default.
- W2279106504 cites W2164489995 @default.
- W2279106504 hasPublicationYear "2009" @default.
- W2279106504 type Work @default.
- W2279106504 sameAs 2279106504 @default.
- W2279106504 citedByCount "0" @default.
- W2279106504 crossrefType "journal-article" @default.
- W2279106504 hasAuthorship W2279106504A5049387464 @default.
- W2279106504 hasConcept C105702510 @default.
- W2279106504 hasConcept C111919701 @default.
- W2279106504 hasConcept C169760540 @default.
- W2279106504 hasConcept C179253579 @default.
- W2279106504 hasConcept C2777004073 @default.
- W2279106504 hasConcept C41008148 @default.
- W2279106504 hasConcept C46762472 @default.
- W2279106504 hasConcept C529278444 @default.
- W2279106504 hasConcept C545314008 @default.
- W2279106504 hasConcept C545706735 @default.
- W2279106504 hasConcept C86803240 @default.
- W2279106504 hasConcept C94487597 @default.
- W2279106504 hasConceptScore W2279106504C105702510 @default.
- W2279106504 hasConceptScore W2279106504C111919701 @default.
- W2279106504 hasConceptScore W2279106504C169760540 @default.
- W2279106504 hasConceptScore W2279106504C179253579 @default.
- W2279106504 hasConceptScore W2279106504C2777004073 @default.
- W2279106504 hasConceptScore W2279106504C41008148 @default.
- W2279106504 hasConceptScore W2279106504C46762472 @default.
- W2279106504 hasConceptScore W2279106504C529278444 @default.
- W2279106504 hasConceptScore W2279106504C545314008 @default.
- W2279106504 hasConceptScore W2279106504C545706735 @default.
- W2279106504 hasConceptScore W2279106504C86803240 @default.
- W2279106504 hasConceptScore W2279106504C94487597 @default.
- W2279106504 hasLocation W22791065041 @default.
- W2279106504 hasOpenAccess W2279106504 @default.
- W2279106504 hasPrimaryLocation W22791065041 @default.
- W2279106504 hasRelatedWork W126989778 @default.
- W2279106504 hasRelatedWork W1504237007 @default.
- W2279106504 hasRelatedWork W187645156 @default.
- W2279106504 hasRelatedWork W189211965 @default.
- W2279106504 hasRelatedWork W2005522138 @default.
- W2279106504 hasRelatedWork W2054230544 @default.
- W2279106504 hasRelatedWork W2079896411 @default.
- W2279106504 hasRelatedWork W2131674028 @default.
- W2279106504 hasRelatedWork W2153104965 @default.
- W2279106504 hasRelatedWork W2202867963 @default.
- W2279106504 hasRelatedWork W2230319452 @default.
- W2279106504 hasRelatedWork W2293152092 @default.
- W2279106504 hasRelatedWork W2335086326 @default.
- W2279106504 hasRelatedWork W2756633005 @default.
- W2279106504 hasRelatedWork W2811485141 @default.
- W2279106504 hasRelatedWork W2955907034 @default.
- W2279106504 hasRelatedWork W3177568458 @default.
- W2279106504 hasRelatedWork W48864328 @default.
- W2279106504 hasRelatedWork W546191 @default.
- W2279106504 hasRelatedWork W66827605 @default.
- W2279106504 isParatext "false" @default.
- W2279106504 isRetracted "false" @default.
- W2279106504 magId "2279106504" @default.
- W2279106504 workType "article" @default.