Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279156285> ?p ?o ?g. }
- W2279156285 abstract "Recent developments in automation and novel experimental techniques have led to the accumulation of vast amounts of biological data and the emergence of numerous databases to store the wealth of information. Consequentially, bioinformatics have drawn considerable attention, accompanied by the development of a plethora of tools for the analysis of biological data. DNA microarrays constitute a prominent example of a high-throughput experimental technique that has required substantial contribution of bioinformatics tools. Following its popularity there is an on-going effort to integrate gene expression with other types of data in a common analytical approach. Pathway based microarray analysis seeks to facilitate microarray data in conjunction with biochemical pathway data and look for a coordinated change in the expression of genes constituting a pathway. However, it has been observed that genes in a pathway may show variable expression, with some appearing activated while others repressed. This thesis aims to add some contribution to pathway based microarray analysis and assist the interpretation of such observations, based on the fact that in all organisms a substantial number of genes take part in more than one biochemical pathway. It explores the hypothesis that the expression of such genes represents a net effect of their contribution to all their constituent pathways, applying statistical and data mining approaches. A heuristic search methodology is proposed to manipulate the pathway contribution of genes to follow underlying trends and interpret microarray results centred on pathway behaviour. The methodology is further refined to account for distinct genes encoding enzymes that catalyse the same reaction, and applied to modules, shorter chains of reactions forming sub-networks within pathways. Results based on various datasets are discussed, showing that the methodology is promising and may assist a biologist to decipher the biochemical state of an organism, in experiments where pathways exhibit variable expression." @default.
- W2279156285 created "2016-06-24" @default.
- W2279156285 creator A5044613710 @default.
- W2279156285 date "2011-01-01" @default.
- W2279156285 modified "2023-09-23" @default.
- W2279156285 title "Pathway based microarray analysis based on multi-membership gene regulation" @default.
- W2279156285 cites W1497256448 @default.
- W2279156285 cites W1508419498 @default.
- W2279156285 cites W1527571715 @default.
- W2279156285 cites W1544923801 @default.
- W2279156285 cites W1558365920 @default.
- W2279156285 cites W1588488206 @default.
- W2279156285 cites W1604281503 @default.
- W2279156285 cites W1768619703 @default.
- W2279156285 cites W1844712574 @default.
- W2279156285 cites W1962003619 @default.
- W2279156285 cites W1970156673 @default.
- W2279156285 cites W1971539696 @default.
- W2279156285 cites W1976434307 @default.
- W2279156285 cites W1978486653 @default.
- W2279156285 cites W1981509058 @default.
- W2279156285 cites W1988037647 @default.
- W2279156285 cites W1988319444 @default.
- W2279156285 cites W1988743517 @default.
- W2279156285 cites W1992419399 @default.
- W2279156285 cites W1992595091 @default.
- W2279156285 cites W1999062346 @default.
- W2279156285 cites W2000522196 @default.
- W2279156285 cites W2002246796 @default.
- W2279156285 cites W2002995168 @default.
- W2279156285 cites W2004975621 @default.
- W2279156285 cites W2005923596 @default.
- W2279156285 cites W2009135239 @default.
- W2279156285 cites W2014993313 @default.
- W2279156285 cites W2015705446 @default.
- W2279156285 cites W2016493165 @default.
- W2279156285 cites W2016954850 @default.
- W2279156285 cites W2017578869 @default.
- W2279156285 cites W2021239799 @default.
- W2279156285 cites W2022128518 @default.
- W2279156285 cites W2024060531 @default.
- W2279156285 cites W2027670788 @default.
- W2279156285 cites W2028133290 @default.
- W2279156285 cites W2028959752 @default.
- W2279156285 cites W2029441111 @default.
- W2279156285 cites W2039992584 @default.
- W2279156285 cites W2045487373 @default.
- W2279156285 cites W2047928920 @default.
- W2279156285 cites W2050326101 @default.
- W2279156285 cites W2055043387 @default.
- W2279156285 cites W2059361536 @default.
- W2279156285 cites W2065649479 @default.
- W2279156285 cites W2067229758 @default.
- W2279156285 cites W2069270085 @default.
- W2279156285 cites W2079056345 @default.
- W2279156285 cites W2079751048 @default.
- W2279156285 cites W2094883982 @default.
- W2279156285 cites W2098528368 @default.
- W2279156285 cites W2098601504 @default.
- W2279156285 cites W2100167673 @default.
- W2279156285 cites W2100474154 @default.
- W2279156285 cites W210059902 @default.
- W2279156285 cites W2103327413 @default.
- W2279156285 cites W2107363136 @default.
- W2279156285 cites W2107603310 @default.
- W2279156285 cites W2108671185 @default.
- W2279156285 cites W2108728387 @default.
- W2279156285 cites W2110365947 @default.
- W2279156285 cites W2115213105 @default.
- W2279156285 cites W2116166762 @default.
- W2279156285 cites W2117116259 @default.
- W2279156285 cites W2117391818 @default.
- W2279156285 cites W2119004102 @default.
- W2279156285 cites W2119166302 @default.
- W2279156285 cites W2120973253 @default.
- W2279156285 cites W2121923468 @default.
- W2279156285 cites W2123060905 @default.
- W2279156285 cites W2127218421 @default.
- W2279156285 cites W2128601422 @default.
- W2279156285 cites W2130410032 @default.
- W2279156285 cites W2133034723 @default.
- W2279156285 cites W2133376865 @default.
- W2279156285 cites W2134153749 @default.
- W2279156285 cites W2135656292 @default.
- W2279156285 cites W2135681892 @default.
- W2279156285 cites W2137683543 @default.
- W2279156285 cites W2137839234 @default.
- W2279156285 cites W2138073318 @default.
- W2279156285 cites W2140864052 @default.
- W2279156285 cites W2141132558 @default.
- W2279156285 cites W2143784594 @default.
- W2279156285 cites W2148101811 @default.
- W2279156285 cites W2148151865 @default.
- W2279156285 cites W2149209973 @default.
- W2279156285 cites W2150389507 @default.
- W2279156285 cites W2150926065 @default.
- W2279156285 cites W2155331065 @default.
- W2279156285 cites W2156779720 @default.
- W2279156285 cites W2159675211 @default.
- W2279156285 cites W2163956552 @default.