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- W2279162851 abstract "Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by a central cholinergic deficit. Non-neuronal cholinergic changes are, however, described as well. Here we focused on possible changes in the activity of the plasma cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), in hospitalized AD patients. We analyzed plasma AChE and BChE activities with regards to age, gender, body mass index (BMI), cognitive functions, and ability to perform activities of daily living in AD patients in comparison to healthy subjects. We observed lower AChE activity and trend toward lower BChE activity in AD patients, which both correlated with low BMI. AD patients unable to perform basic activities of daily living (feeding, bathing, dressing, and grooming) showed reduced plasma AChE activities, while worse spatial orientation was linked to lower BChE activities. Three out of four AD patients with the lowest BChE activities died within one year. In conclusion, progressed AD was accompanied by lower plasma AChE activity and trend toward lower BChE activity, which correlated with BMI and deficits in different components of the AD." @default.
- W2279162851 created "2016-06-24" @default.
- W2279162851 creator A5003162493 @default.
- W2279162851 creator A5003715929 @default.
- W2279162851 creator A5009977846 @default.
- W2279162851 creator A5015838908 @default.
- W2279162851 creator A5017318702 @default.
- W2279162851 creator A5067544576 @default.
- W2279162851 date "2016-03-30" @default.
- W2279162851 modified "2023-10-14" @default.
- W2279162851 title "Low Plasma Cholinesterase Activities are Associated with Deficits in Spatial Orientation, Reduced Ability to Perform Basic Activities of Daily Living, and Low Body Mass Index in Patients with Progressed Alzheimer’s Disease" @default.
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