FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279233591> ?p ?o ?g. }

• W2279233591 endingPage "259" @default.
• W2279233591 startingPage "248" @default.
• W2279233591 abstract "Oligomeric and fibrillar beta-amyloid (Abeta) may be toxic in Alzheimer disease (AD), especially after post-translation modification cumulative over time. Racemization of Ser and Asp residues of Abeta in senile plaques (SPs) occurs as an age-dependent process in AD. We previously reported that Abeta1-40 racemized at Ser26 is soluble and susceptible to proteolysis yielding toxic [D-Ser26]Abeta25-35/40 fragments in vitro and in vivo. Here, we focus on the localization of racemized Ser26 residues in AD brains within the limbic system, the earliest site of AD histopathology. We developed antisera (20.1 and 22.7). each with epitopes within [D-Ser26]Abeta25-40. Two forms of truncated [D-Ser26]Abeta were detected either in SPs or within neurons in all 11 AD-affected brains, but not in age-matched controls. [D-Ser26]Abeta25/26-35 (detected by 20.1) was localized to plaque cores, extracellular neurofibrillary ghost tangles and vascular amyloid deposits. In contrast, [D-Ser26]Abeta25-40 (detected by 22.7) was observed in most neurons containing intracellular neurofibrillary tangles, but not in SPs. These results suggest [D-Ser26]Abeta]1-40, formed during aging, becomes soluble and diffuses from SPs. It is then proteolyzed to [D-Ser26]Abeta25-35/40, which is toxic and may contribute to the neurodegeneration. This hypothesis may explain the long lag between SP formation and neurofibrillary degeneration in AD brains." @default.
• W2279233591 created "2016-06-24" @default.
• W2279233591 creator A5004141488 @default.
• W2279233591 creator A5012091198 @default.
• W2279233591 creator A5054365476 @default.
• W2279233591 creator A5059296190 @default.
• W2279233591 date "2003-03-01" @default.
• W2279233591 modified "2023-10-09" @default.
• W2279233591 title "β-Amyloid Racemized at the Ser²⁶Residue in the Brains of Patients with Alzheimer Disease: Implications in the Pathogenesis of Alzheimer Disease" @default.
• W2279233591 cites W1495429911 @default.
• W2279233591 cites W1960543132 @default.
• W2279233591 cites W1965093146 @default.
• W2279233591 cites W1972567838 @default.
• W2279233591 cites W1972891705 @default.
• W2279233591 cites W1979545503 @default.
• W2279233591 cites W1981677626 @default.
• W2279233591 cites W1999437155 @default.
• W2279233591 cites W2001210466 @default.
• W2279233591 cites W2010255726 @default.
• W2279233591 cites W2013471403 @default.
• W2279233591 cites W2015349765 @default.
• W2279233591 cites W2035235911 @default.
• W2279233591 cites W2037900145 @default.
• W2279233591 cites W2041789591 @default.
• W2279233591 cites W2044388435 @default.
• W2279233591 cites W2046680150 @default.
• W2279233591 cites W2048532208 @default.
• W2279233591 cites W2048975745 @default.
• W2279233591 cites W2052742260 @default.
• W2279233591 cites W2053116497 @default.
• W2279233591 cites W2059214757 @default.
• W2279233591 cites W2063236931 @default.
• W2279233591 cites W2065611309 @default.
• W2279233591 cites W2069479156 @default.
• W2279233591 cites W2082452187 @default.
• W2279233591 cites W2095422335 @default.
• W2279233591 cites W2095745901 @default.
• W2279233591 cites W2101665091 @default.
• W2279233591 cites W2108689038 @default.
• W2279233591 cites W2126800086 @default.
• W2279233591 cites W2155571475 @default.
• W2279233591 cites W58149416 @default.
• W2279233591 doi "https://doi.org/10.1093/jnen/62.3.248" @default.
• W2279233591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12638729" @default.
• W2279233591 hasPublicationYear "2003" @default.
• W2279233591 type Work @default.
• W2279233591 sameAs 2279233591 @default.
• W2279233591 citedByCount "58" @default.
• W2279233591 countsByYear W22792335912012 @default.
• W2279233591 countsByYear W22792335912013 @default.
• W2279233591 countsByYear W22792335912014 @default.
• W2279233591 countsByYear W22792335912015 @default.
• W2279233591 countsByYear W22792335912016 @default.
• W2279233591 countsByYear W22792335912017 @default.
• W2279233591 countsByYear W22792335912019 @default.
• W2279233591 countsByYear W22792335912020 @default.
• W2279233591 countsByYear W22792335912021 @default.
• W2279233591 countsByYear W22792335912022 @default.
• W2279233591 countsByYear W22792335912023 @default.
• W2279233591 crossrefType "journal-article" @default.
• W2279233591 hasAuthorship W2279233591A5004141488 @default.
• W2279233591 hasAuthorship W2279233591A5012091198 @default.
• W2279233591 hasAuthorship W2279233591A5054365476 @default.
• W2279233591 hasAuthorship W2279233591A5059296190 @default.
• W2279233591 hasConcept C12554922 @default.
• W2279233591 hasConcept C142724271 @default.
• W2279233591 hasConcept C181199279 @default.
• W2279233591 hasConcept C185592680 @default.
• W2279233591 hasConcept C207001950 @default.
• W2279233591 hasConcept C2776925932 @default.
• W2279233591 hasConcept C2777633098 @default.
• W2279233591 hasConcept C2779134260 @default.
• W2279233591 hasConcept C2780942790 @default.
• W2279233591 hasConcept C2781307694 @default.
• W2279233591 hasConcept C28406088 @default.
• W2279233591 hasConcept C502032728 @default.
• W2279233591 hasConcept C54355233 @default.
• W2279233591 hasConcept C55493867 @default.
• W2279233591 hasConcept C68026918 @default.
• W2279233591 hasConcept C71924100 @default.
• W2279233591 hasConcept C86803240 @default.
• W2279233591 hasConceptScore W2279233591C12554922 @default.
• W2279233591 hasConceptScore W2279233591C142724271 @default.
• W2279233591 hasConceptScore W2279233591C181199279 @default.
• W2279233591 hasConceptScore W2279233591C185592680 @default.
• W2279233591 hasConceptScore W2279233591C207001950 @default.
• W2279233591 hasConceptScore W2279233591C2776925932 @default.
• W2279233591 hasConceptScore W2279233591C2777633098 @default.
• W2279233591 hasConceptScore W2279233591C2779134260 @default.
• W2279233591 hasConceptScore W2279233591C2780942790 @default.
• W2279233591 hasConceptScore W2279233591C2781307694 @default.
• W2279233591 hasConceptScore W2279233591C28406088 @default.
• W2279233591 hasConceptScore W2279233591C502032728 @default.
• W2279233591 hasConceptScore W2279233591C54355233 @default.
• W2279233591 hasConceptScore W2279233591C55493867 @default.
• W2279233591 hasConceptScore W2279233591C68026918 @default.
• W2279233591 hasConceptScore W2279233591C71924100 @default.
• W2279233591 hasConceptScore W2279233591C86803240 @default.

• next