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- W2279249957 abstract "Objective:To investigate the expression of vasohibin-1,and its correlations with the clinicopathological features of epithelial ovarian cancers.Methods:Vasohibin-1 mRNA and protein levels were detected in 12 cases of normal ovarian tissues and 60 cases of epithelial ovarian cancer tissues by real-time PCR analysis and immunohistochemisty staining.VEGF protein levels in ovarian cancer tissues were detected by ELISA.The relationship between the expression levels of vasohibin-1 and clinicopathological features was analysis.Results:The levels of vasohibin-1 mRNA and protein were higher in epithelial ovarian cancers than those in normal ovarian tissues(P0.05).The expression of vasohibin-1 correlated with ovarian cancer stage(P0.05),but it had no correlation with differentiation degree and the lymph node metastasis.The levels of vasohibin-1 significantly correlated with VEGF levels in ovarian cancers(P0.01).The prognosis of the 30 patients with high vasohibin-1 expression in ovarian cancers were poor(survival rate 50%),while the 36 months survival rate of the other patients with weak vasohibin-1 expression was 83%.Conclusions:Vasohibin-1 may reflects the angiogenic potential of ovarian cancers and acts as a prognostic factor." @default.
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- W2279249957 date "2010-01-01" @default.
- W2279249957 modified "2023-09-24" @default.
- W2279249957 title "Expression of vasohibin-1 and its relationship with clinicopathologic characteristics in epithelial ovarian cancers." @default.
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