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- W2279291025 abstract "Purpose: To evaluate the changes in corneal fine structure of diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, compared with age-matched nondiabetic rats. Methods: At the ages of 30 and 50 weeks, we measured the body weight and blood glucose level of OELTF and control rats (n=5 in each age-matched group). Using the transmission electron micrography (TEM), we examined the ultrastructural changes between the corneas of 30-and 50-week-old OLETF and control rats. Results: At the age of 30 and 50 weeks, the mean body weight and blood glucose levels of OLETF rats were significantly higher than those of control rats (p0.05). Conclusions: The author could observe the changes of the corneal adherent complex and basement membrane in OLETF rats, a new strain of spontaneous non-insulin dependent diabetes mellitus (NIDDM) model. OLETF rats may be useful as an animal model of NIDDM to examine the diabetic corneal changes." @default.
- W2279291025 created "2016-06-24" @default.
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- W2279291025 date "2004-05-01" @default.
- W2279291025 modified "2023-09-28" @default.
- W2279291025 title "Ultrastructural Changes in Corneas of Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats." @default.
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