Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279303008> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2279303008 endingPage "80" @default.
- W2279303008 startingPage "471" @default.
- W2279303008 abstract "The 67-kDa protein identical to the enzymatically inactive spliced variant of beta-galactosidase is a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. It recognizes several non-identical hydrophobic domains on elastin, laminin, and type IV collagen, provided they form a similar secondary conformation. The 67-kDa protein is not a transmembrane molecule, but immobilizes on the cell surface by an association with two other proteins, the 61-kDa neuraminidase and the 55-kDa 'protective protein'. The 67-kDa protein binds to matrix ligands in a calcium independent manner and only in the absence of galactosugars. Binding of these carbohydrate-bearing moieties causes such conformational changes of the 67-kDa protein that it loses the ability to bind its principal matrix ligands and separates from the cell surface. Galactosugars which inactivate this unique cell surface receptor may therefore modulate cell-matrix interactions, especially in such processes as SMC migration during vascular thickening, tumor cell metastasis, or tissue infiltration by the leukocytes. In elastin-producing cells, the 67-kDa protein associates with tropoelastin and serves as a molecular chaperone which facilitates its intracellular transport and extracellular assembly." @default.
- W2279303008 created "2016-06-24" @default.
- W2279303008 creator A5062907362 @default.
- W2279303008 date "1996-07-01" @default.
- W2279303008 modified "2023-10-18" @default.
- W2279303008 title "Biological roles of the non-integrin elastin/laminin receptor." @default.
- W2279303008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8922281" @default.
- W2279303008 hasPublicationYear "1996" @default.
- W2279303008 type Work @default.
- W2279303008 sameAs 2279303008 @default.
- W2279303008 citedByCount "43" @default.
- W2279303008 countsByYear W22793030082012 @default.
- W2279303008 countsByYear W22793030082013 @default.
- W2279303008 countsByYear W22793030082014 @default.
- W2279303008 countsByYear W22793030082015 @default.
- W2279303008 countsByYear W22793030082016 @default.
- W2279303008 countsByYear W22793030082018 @default.
- W2279303008 crossrefType "journal-article" @default.
- W2279303008 hasAuthorship W2279303008A5062907362 @default.
- W2279303008 hasConcept C1491633281 @default.
- W2279303008 hasConcept C170493617 @default.
- W2279303008 hasConcept C185592680 @default.
- W2279303008 hasConcept C189165786 @default.
- W2279303008 hasConcept C195687474 @default.
- W2279303008 hasConcept C197462201 @default.
- W2279303008 hasConcept C24530287 @default.
- W2279303008 hasConcept C2779814568 @default.
- W2279303008 hasConcept C2779869378 @default.
- W2279303008 hasConcept C2780299668 @default.
- W2279303008 hasConcept C54355233 @default.
- W2279303008 hasConcept C55493867 @default.
- W2279303008 hasConcept C86492073 @default.
- W2279303008 hasConcept C86803240 @default.
- W2279303008 hasConcept C95444343 @default.
- W2279303008 hasConceptScore W2279303008C1491633281 @default.
- W2279303008 hasConceptScore W2279303008C170493617 @default.
- W2279303008 hasConceptScore W2279303008C185592680 @default.
- W2279303008 hasConceptScore W2279303008C189165786 @default.
- W2279303008 hasConceptScore W2279303008C195687474 @default.
- W2279303008 hasConceptScore W2279303008C197462201 @default.
- W2279303008 hasConceptScore W2279303008C24530287 @default.
- W2279303008 hasConceptScore W2279303008C2779814568 @default.
- W2279303008 hasConceptScore W2279303008C2779869378 @default.
- W2279303008 hasConceptScore W2279303008C2780299668 @default.
- W2279303008 hasConceptScore W2279303008C54355233 @default.
- W2279303008 hasConceptScore W2279303008C55493867 @default.
- W2279303008 hasConceptScore W2279303008C86492073 @default.
- W2279303008 hasConceptScore W2279303008C86803240 @default.
- W2279303008 hasConceptScore W2279303008C95444343 @default.
- W2279303008 hasIssue "7-8" @default.
- W2279303008 hasLocation W22793030081 @default.
- W2279303008 hasOpenAccess W2279303008 @default.
- W2279303008 hasPrimaryLocation W22793030081 @default.
- W2279303008 hasRelatedWork W183222978 @default.
- W2279303008 hasRelatedWork W1970559721 @default.
- W2279303008 hasRelatedWork W1981933399 @default.
- W2279303008 hasRelatedWork W1993983073 @default.
- W2279303008 hasRelatedWork W2088017097 @default.
- W2279303008 hasRelatedWork W2143764756 @default.
- W2279303008 hasRelatedWork W2214874215 @default.
- W2279303008 hasRelatedWork W2279303008 @default.
- W2279303008 hasRelatedWork W3216120337 @default.
- W2279303008 hasRelatedWork W338192754 @default.
- W2279303008 hasVolume "377" @default.
- W2279303008 isParatext "false" @default.
- W2279303008 isRetracted "false" @default.
- W2279303008 magId "2279303008" @default.
- W2279303008 workType "article" @default.