Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279303908> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2279303908 abstract "We hypothesized that secoisolariciresinol diglucoside (SDG, Beneflax™) derived from flaxseed, would lower serum cholesterol in hypercholesterolemic humans and that the effect would be correlated with serum lignan metabolites. 90 subjects ingested 0 mg (18 male, 12 female), 150 mg (19 male, 11 female), or 300 mg SDG (, 20 male, 10 female) total daily dose for 12 w in a randomized, placebo-controlled double-blind trial. At 0 and 12 weeks, serum secoisolariciresinol (SECO), enterodiol (ED), and enterolactone (EL) were measured by LC/MS. Fasting serum cholesterol, glucose, and HbA1c were measured at −2, 0, 4, 8 and 12 wks. Decrease of total cholesterol (TC) and LDL-cholesterol (LDL-C) from baseline were significant in men ingesting either dose of SDG. Plasma glucose was not changed from baseline by any treatment. The decrease of TC and LDL-C from baseline was significantly greater in men than in women ingesting 300 mg SDG/d. Serum SECO, EL and ED were significantly increased in subjects ingesting either dose of lignans. LDL-C was negatively correlated with serum ED (r = − 0.50, P = 0.03); and LDL decrease from baseline was positively correlated with serum SECO (r = 0.59, P = 0.01) in subjects ingesting 150 mg SDG/d. In conclusion, SDG decreased serum TC and LDL-C in men but not in women and this function was related to the bioavailability of lignan metabolites. Research funded by Archer Daniels Midland. Grant Funding Source: Archer Daniels Midland" @default.
- W2279303908 created "2016-06-24" @default.
- W2279303908 creator A5015339043 @default.
- W2279303908 creator A5016112776 @default.
- W2279303908 creator A5016414784 @default.
- W2279303908 creator A5023267063 @default.
- W2279303908 creator A5025939565 @default.
- W2279303908 creator A5051160771 @default.
- W2279303908 date "2010-04-01" @default.
- W2279303908 modified "2023-09-28" @default.
- W2279303908 title "Men and not women showed cholesterol lowering after 12 weeks of supplementation with secoisolariciresinol diglucoside" @default.
- W2279303908 doi "https://doi.org/10.1096/fasebj.24.1_supplement.219.8" @default.
- W2279303908 hasPublicationYear "2010" @default.
- W2279303908 type Work @default.
- W2279303908 sameAs 2279303908 @default.
- W2279303908 citedByCount "0" @default.
- W2279303908 crossrefType "journal-article" @default.
- W2279303908 hasAuthorship W2279303908A5015339043 @default.
- W2279303908 hasAuthorship W2279303908A5016112776 @default.
- W2279303908 hasAuthorship W2279303908A5016414784 @default.
- W2279303908 hasAuthorship W2279303908A5023267063 @default.
- W2279303908 hasAuthorship W2279303908A5025939565 @default.
- W2279303908 hasAuthorship W2279303908A5051160771 @default.
- W2279303908 hasConcept C126322002 @default.
- W2279303908 hasConcept C134018914 @default.
- W2279303908 hasConcept C142724271 @default.
- W2279303908 hasConcept C181389837 @default.
- W2279303908 hasConcept C185592680 @default.
- W2279303908 hasConcept C204787440 @default.
- W2279303908 hasConcept C27081682 @default.
- W2279303908 hasConcept C2777164284 @default.
- W2279303908 hasConcept C2777927066 @default.
- W2279303908 hasConcept C2778163477 @default.
- W2279303908 hasConcept C2778270713 @default.
- W2279303908 hasConcept C2781264555 @default.
- W2279303908 hasConcept C71240020 @default.
- W2279303908 hasConcept C71924100 @default.
- W2279303908 hasConcept C98274493 @default.
- W2279303908 hasConceptScore W2279303908C126322002 @default.
- W2279303908 hasConceptScore W2279303908C134018914 @default.
- W2279303908 hasConceptScore W2279303908C142724271 @default.
- W2279303908 hasConceptScore W2279303908C181389837 @default.
- W2279303908 hasConceptScore W2279303908C185592680 @default.
- W2279303908 hasConceptScore W2279303908C204787440 @default.
- W2279303908 hasConceptScore W2279303908C27081682 @default.
- W2279303908 hasConceptScore W2279303908C2777164284 @default.
- W2279303908 hasConceptScore W2279303908C2777927066 @default.
- W2279303908 hasConceptScore W2279303908C2778163477 @default.
- W2279303908 hasConceptScore W2279303908C2778270713 @default.
- W2279303908 hasConceptScore W2279303908C2781264555 @default.
- W2279303908 hasConceptScore W2279303908C71240020 @default.
- W2279303908 hasConceptScore W2279303908C71924100 @default.
- W2279303908 hasConceptScore W2279303908C98274493 @default.
- W2279303908 hasFunder F4320311877 @default.
- W2279303908 hasIssue "S1" @default.
- W2279303908 hasLocation W22793039081 @default.
- W2279303908 hasOpenAccess W2279303908 @default.
- W2279303908 hasPrimaryLocation W22793039081 @default.
- W2279303908 hasRelatedWork W1966834268 @default.
- W2279303908 hasRelatedWork W1972175381 @default.
- W2279303908 hasRelatedWork W2005998106 @default.
- W2279303908 hasRelatedWork W2032958076 @default.
- W2279303908 hasRelatedWork W2035331946 @default.
- W2279303908 hasRelatedWork W2070692913 @default.
- W2279303908 hasRelatedWork W2075372262 @default.
- W2279303908 hasRelatedWork W2099093704 @default.
- W2279303908 hasRelatedWork W2748952813 @default.
- W2279303908 hasRelatedWork W4242761889 @default.
- W2279303908 hasVolume "24" @default.
- W2279303908 isParatext "false" @default.
- W2279303908 isRetracted "false" @default.
- W2279303908 magId "2279303908" @default.
- W2279303908 workType "article" @default.