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- W2279342937 abstract "METHODS: Observational study using data from medical records of 41 girls with IPP aged 4-10 years attended at the Paediatric Outpatients Clinic of the University of Blumenau between 1999 and 2013. Excess weight (overweight and obesity according WHO criteria), blood pressure, low birth weight ( 150mg/dL or LDL-c >100mg/dL or HDL-c 100mg/dL), basal blood androgens levels (17-OH-progesterone, androstenedione, DHEA-S and total testosterone), hyperinsulinism (basal insulin >15mUI/L) and insulin resistance (HOMA-IR >3.16) were analysed. The appearance of pubarche before 8 years without breast development was considered IPP. In the presence of advanced bone age (>1 year) and elevated basal blood androgens levels an adrenal stimulation test with exogenous ACTH was performed to ruled out congenital adrenal hyperplasia. RESULTS: The mean age at the first medical evaluation was 7.8 ± 1.4 years. Clinical and biochemical parameters are presented in Table 1. Excess weight was present in 42.1% (26.3% overweight and 15,8% obesity), elevated blood pressure in 17.3% and dyslipidaemia in 45.8%. Hyperinsulinism and insulin resistance were not observed. However the group with excess weight had fasting insulin levels higher than excess weight group (7.3±4.2 vs 4.3±2.8; p<0.05). Bone age was advanced in 81.8%. Basal blood levels of 17-OH-progesterone, androstenedione, DHEA-S and total testosterone were elevated in 48.6%, 35.1%, 32.4% and 37.2% respectively. Low birth weight ocurred in 13.1%. OBJECTIVE: To evaluate the frequency of cardiovascular disease risk factors in girls with isolated premature pubarche (IPP)." @default.
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- W2279342937 date "2015-08-26" @default.
- W2279342937 modified "2023-09-23" @default.
- W2279342937 title "Cardiovascular Disease Risk Factors in Girls with Isolated Premature Pubarche" @default.
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