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• W2279344059 abstract "Chronic psychological stress is associated with enhanced abdominal pain and altered intestinal barrier function that may result from a perturbation in the hypothalamic-pituitary-adrenal (HPA) axis. The glucocorticoid receptor (GR) exploits diverse mechanisms to activate or suppress congeneric gene expression, with regulatory variation associated with stress-related disorders in psychiatry and gastroenterology.During acute and chronic stress, corticotropin-releasing hormone drives secretion of adrenocorticotropic hormone from the pituitary, ultimately leading to the release of cortisol (human) and corticosterone (rodent) from the adrenal glands. Cortisol binds with the GR in the cytosol, translocates to the nucleus, and activates the NR3C1 (nuclear receptor subfamily 3, group C, member 1 [GR]) gene. This review focuses on the rapidly developing observations that cortisol is responsible for driving circadian and ultradian bursts of transcriptional activity in the CLOCK (clock circadian regulator) and PER (period circadian clock 1) gene families, and this rhythm is disrupted in major depressive disorder, bipolar disorder, and stress-related gastrointestinal and immune disorders. Glucocorticoid receptor regulates different sets of transcripts in a tissue-specific manner, through pulsatile waves of gene expression that includes occupancy of glucocorticoid response elements located within constitutively open spatial domains in chromatin. Emerging evidence supports a potentially pivotal role for epigenetic regulation of how GR interacts with other chromatin regulators to control the expression of its target genes. Dysregulation of the central and peripheral GR regulome has potentially significant consequences for stress-related disorders affecting the brain-gut axis." @default.
• W2279344059 created "2016-06-24" @default.
• W2279344059 creator A5010326920 @default.
• W2279344059 creator A5022058940 @default.
• W2279344059 creator A5032771078 @default.
• W2279344059 date "2015-12-21" @default.
• W2279344059 modified "2023-09-24" @default.
• W2279344059 title "Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain-gut axis" @default.
• W2279344059 cites W1489339892 @default.
• W2279344059 cites W1501268789 @default.
• W2279344059 cites W1514788018 @default.
• W2279344059 cites W1577268011 @default.
• W2279344059 cites W1582154931 @default.
• W2279344059 cites W19586842 @default.
• W2279344059 cites W1963958393 @default.
• W2279344059 cites W1966598101 @default.
• W2279344059 cites W1968434023 @default.
• W2279344059 cites W1968721722 @default.
• W2279344059 cites W1970831058 @default.
• W2279344059 cites W1973590155 @default.
• W2279344059 cites W1974636874 @default.
• W2279344059 cites W1979951319 @default.
• W2279344059 cites W1981629278 @default.
• W2279344059 cites W1982232439 @default.
• W2279344059 cites W1982519328 @default.
• W2279344059 cites W1983530018 @default.
• W2279344059 cites W1984417371 @default.
• W2279344059 cites W1987167904 @default.
• W2279344059 cites W1987375729 @default.
• W2279344059 cites W1991723608 @default.
• W2279344059 cites W1995562162 @default.
• W2279344059 cites W1998000745 @default.
• W2279344059 cites W2001420067 @default.
• W2279344059 cites W2001540932 @default.
• W2279344059 cites W2001554877 @default.
• W2279344059 cites W2004200479 @default.
• W2279344059 cites W2004539856 @default.
• W2279344059 cites W2004611823 @default.
• W2279344059 cites W2004849589 @default.
• W2279344059 cites W2005229523 @default.
• W2279344059 cites W2006819023 @default.
• W2279344059 cites W2006994181 @default.
• W2279344059 cites W2007169317 @default.
• W2279344059 cites W2007625102 @default.
• W2279344059 cites W2007816528 @default.
• W2279344059 cites W2008654807 @default.
• W2279344059 cites W2009721053 @default.
• W2279344059 cites W2010847026 @default.
• W2279344059 cites W2017606565 @default.
• W2279344059 cites W2018317221 @default.
• W2279344059 cites W2018630482 @default.
• W2279344059 cites W2020185368 @default.
• W2279344059 cites W2021650173 @default.
• W2279344059 cites W2026930722 @default.
• W2279344059 cites W2030498475 @default.
• W2279344059 cites W2031041075 @default.
• W2279344059 cites W2032200433 @default.
• W2279344059 cites W2032245465 @default.
• W2279344059 cites W2034722299 @default.
• W2279344059 cites W2035649348 @default.
• W2279344059 cites W2036194871 @default.
• W2279344059 cites W2037024585 @default.
• W2279344059 cites W2039423366 @default.
• W2279344059 cites W2040339296 @default.
• W2279344059 cites W2042336558 @default.
• W2279344059 cites W2042500733 @default.
• W2279344059 cites W2043153024 @default.
• W2279344059 cites W2045217053 @default.
• W2279344059 cites W2047059900 @default.
• W2279344059 cites W2053472601 @default.
• W2279344059 cites W2053500303 @default.
• W2279344059 cites W2059633037 @default.
• W2279344059 cites W2060012727 @default.
• W2279344059 cites W2062722848 @default.
• W2279344059 cites W2062989629 @default.
• W2279344059 cites W2063946784 @default.
• W2279344059 cites W2064891540 @default.
• W2279344059 cites W2066438189 @default.
• W2279344059 cites W2067181732 @default.
• W2279344059 cites W2071153571 @default.
• W2279344059 cites W2073914979 @default.
• W2279344059 cites W2074409078 @default.
• W2279344059 cites W2074906225 @default.
• W2279344059 cites W2075790119 @default.
• W2279344059 cites W2078084967 @default.
• W2279344059 cites W2081781048 @default.
• W2279344059 cites W2082948318 @default.
• W2279344059 cites W2084424064 @default.
• W2279344059 cites W2086152675 @default.
• W2279344059 cites W2090455592 @default.
• W2279344059 cites W2096256974 @default.
• W2279344059 cites W2096447810 @default.
• W2279344059 cites W2096465161 @default.
• W2279344059 cites W2101037833 @default.
• W2279344059 cites W2101451224 @default.
• W2279344059 cites W2103331727 @default.
• W2279344059 cites W2104626099 @default.
• W2279344059 cites W2105144622 @default.

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