Matches in SemOpenAlex for { <https://semopenalex.org/work/W22793838> ?p ?o ?g. }
- W22793838 endingPage "380" @default.
- W22793838 startingPage "374" @default.
- W22793838 abstract "Rotigaptide is a new anti-arrhythmic peptide, which has recently been found to increase junctional conductance and prevent ischemia-induced ventricular tachycardia. In this study, we attempted to investigate the effects and mechanisms of rotigaptide on the vulnerability to ventricular arrhythmias in rabbits with heart failure (HF).Chronic volume-pressure overload was used to induce HF. After rotigaptide infusion, an electrophysiological study was performed to record monophasic action potential (MAP), determine the effective refractory period (ERP) and ventricular fibrillation threshold (VFT), and assess the susceptibility to ventricular arrhythmia. Finally, real-time PCR was used to detect the changes of connexin 43 (Cx43) mRNA expression.HF rabbits exhibited significant down-regulation of Cx43 mRNA, increase of effective refractory period (ERP) and decrease of VFT (p < 0.05, respectively). These changes resulted in an increase of vulnerability to ventricular tachyarrhythmias (VT/VF). Rotigaptide administration shortened ERP (113.3 ±8.6 ms vs. 131.7 ±12.5 ms, p < 0.05), restored VFT (15.0 ±2.0 V vs. 6.3 ±1.4 V, p < 0.05), and decreased the vulnerability to VT/VF. However, short-term rotigaptide treatment had no significant effect on MAP duration (MAP duration at 90% repolarization: 169.3 ±6.0 ms vs. 172.7 ±6.2 ms, p > 0.05) or connexin 43 mRNA expression (p > 0.05).Rotigaptide decreases the ERP, elevates VFT, and reduces the vulnerability to ventricular arrhythmias without changing Cx43 expression in rabbits with HF. It may be a promising antiarrhythmic drug for preventing ventricular arrhythmia in HF." @default.
- W22793838 created "2016-06-24" @default.
- W22793838 creator A5034305048 @default.
- W22793838 creator A5061584676 @default.
- W22793838 creator A5066972544 @default.
- W22793838 creator A5073358520 @default.
- W22793838 creator A5074410045 @default.
- W22793838 creator A5085032833 @default.
- W22793838 date "2014-01-01" @default.
- W22793838 modified "2023-10-16" @default.
- W22793838 title "Experimental study Electrophysiological effect of rotigaptide in rabbits with heart failure" @default.
- W22793838 cites W1547108470 @default.
- W22793838 cites W1974691466 @default.
- W22793838 cites W1976681931 @default.
- W22793838 cites W1984826300 @default.
- W22793838 cites W1986479417 @default.
- W22793838 cites W2004631233 @default.
- W22793838 cites W2017701060 @default.
- W22793838 cites W2024690999 @default.
- W22793838 cites W2027613540 @default.
- W22793838 cites W2038017062 @default.
- W22793838 cites W2050627314 @default.
- W22793838 cites W2056911943 @default.
- W22793838 cites W2064781839 @default.
- W22793838 cites W2073773271 @default.
- W22793838 cites W2082532737 @default.
- W22793838 cites W2083786873 @default.
- W22793838 cites W2084275033 @default.
- W22793838 cites W2099625508 @default.
- W22793838 cites W2103297830 @default.
- W22793838 cites W2110019686 @default.
- W22793838 cites W2131553641 @default.
- W22793838 cites W2138986820 @default.
- W22793838 cites W2142885802 @default.
- W22793838 cites W2143758022 @default.
- W22793838 cites W2147039756 @default.
- W22793838 cites W2150488509 @default.
- W22793838 cites W2152329719 @default.
- W22793838 cites W2159008270 @default.
- W22793838 cites W2160908060 @default.
- W22793838 cites W2161035238 @default.
- W22793838 cites W2162541315 @default.
- W22793838 cites W2165624923 @default.
- W22793838 cites W2166898187 @default.
- W22793838 cites W2167646683 @default.
- W22793838 doi "https://doi.org/10.5114/aoms.2012.31385" @default.
- W22793838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4042033" @default.
- W22793838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24904675" @default.
- W22793838 hasPublicationYear "2014" @default.
- W22793838 type Work @default.
- W22793838 sameAs 22793838 @default.
- W22793838 citedByCount "6" @default.
- W22793838 countsByYear W227938382016 @default.
- W22793838 countsByYear W227938382017 @default.
- W22793838 countsByYear W227938382018 @default.
- W22793838 countsByYear W227938382021 @default.
- W22793838 crossrefType "journal-article" @default.
- W22793838 hasAuthorship W22793838A5034305048 @default.
- W22793838 hasAuthorship W22793838A5061584676 @default.
- W22793838 hasAuthorship W22793838A5066972544 @default.
- W22793838 hasAuthorship W22793838A5073358520 @default.
- W22793838 hasAuthorship W22793838A5074410045 @default.
- W22793838 hasAuthorship W22793838A5085032833 @default.
- W22793838 hasBestOaLocation W227938381 @default.
- W22793838 hasConcept C126322002 @default.
- W22793838 hasConcept C146403970 @default.
- W22793838 hasConcept C158157758 @default.
- W22793838 hasConcept C164705383 @default.
- W22793838 hasConcept C185263204 @default.
- W22793838 hasConcept C189327125 @default.
- W22793838 hasConcept C2776331378 @default.
- W22793838 hasConcept C2777356233 @default.
- W22793838 hasConcept C2778198053 @default.
- W22793838 hasConcept C2779161974 @default.
- W22793838 hasConcept C2780228694 @default.
- W22793838 hasConcept C2781005686 @default.
- W22793838 hasConcept C42219234 @default.
- W22793838 hasConcept C70616116 @default.
- W22793838 hasConcept C71924100 @default.
- W22793838 hasConcept C79879829 @default.
- W22793838 hasConcept C86803240 @default.
- W22793838 hasConcept C95444343 @default.
- W22793838 hasConceptScore W22793838C126322002 @default.
- W22793838 hasConceptScore W22793838C146403970 @default.
- W22793838 hasConceptScore W22793838C158157758 @default.
- W22793838 hasConceptScore W22793838C164705383 @default.
- W22793838 hasConceptScore W22793838C185263204 @default.
- W22793838 hasConceptScore W22793838C189327125 @default.
- W22793838 hasConceptScore W22793838C2776331378 @default.
- W22793838 hasConceptScore W22793838C2777356233 @default.
- W22793838 hasConceptScore W22793838C2778198053 @default.
- W22793838 hasConceptScore W22793838C2779161974 @default.
- W22793838 hasConceptScore W22793838C2780228694 @default.
- W22793838 hasConceptScore W22793838C2781005686 @default.
- W22793838 hasConceptScore W22793838C42219234 @default.
- W22793838 hasConceptScore W22793838C70616116 @default.
- W22793838 hasConceptScore W22793838C71924100 @default.
- W22793838 hasConceptScore W22793838C79879829 @default.