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- W2279389369 abstract "Controlled drug release gained a sharply increasing interest over recent years. Multiple materials have been screened as possible drug carriers, ranging from biodegradable polymers to hydroxyapatite[1]. Periodic Mesoporous Organosilicas are valuable alternatives as they possess a high chemical and thermal stability combined with a biocompatible nature[2]. Furthermore, their large internal surface area permits a high drug loading. Careful selection of the organic ‘bridged’ functionality allows a controlled release with respect to external stimuli, such as pH or temperature, of the drugs which are adsorbed via weak and reversible interactions, e.g. H-bonding and hydrophobic-phobic interaction[3]. In this contribution a novel malonamide (MA-PMO) and a methyl-malonamide PMO (mMA-PMO) bearing a high amount of H-bond donors and acceptors is developed and thoroughly characterised. Subsequently, these hybrid materials are evaluated in the controlled drug release of Ibuprofen." @default.
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- W2279389369 date "2014-01-01" @default.
- W2279389369 modified "2023-09-27" @default.
- W2279389369 title "A novel malonamide Periodic Mesoporous Organosilica (PMO) for controlled ibuprofen release" @default.
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