Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279429536> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2279429536 endingPage "H1796" @default.
- W2279429536 startingPage "H1791" @default.
- W2279429536 abstract "Important side effects of cyclosporin (CSA) are renal insufficiency and hypertension. They might be related to a renal vasoconstrictive effect of CSA, and this vascular response might be due to a local mechanism. CSA was injected in isolated renal artery perfused at constant flow in dogs. Changes in renal perfusion pressure reflected variations in vascular resistance. Pure CSA was dissolved in autologous blood and injected at doses of 0.5, 1, 5, and 10 mg. The infusion of 0.5 and 1 mg caused averaged renal perfusion pressure increases of 8 +/- 4 mmHg and 15 +/- 8 mmHg. Renal venous CSA levels averaged 32 +/- 3 and 49 +/- 9 nmol/l, respectively, at the end of injections. Infusion of 5 and 10 mg of CSA caused averaged renal perfusion pressure increases of 32 +/- 12 mmHg and 81 +/- 21 mmHg. Renal venous CSA levels at the end of injections averaged 142 +/- 30 and 382 +/- 82 nmol/l, respectively. A positive correlation was found between the changes in renal perfusion pressure and renal venous CSA levels. Blockade of alpha-adrenergic receptors, surgical renal sympathectomy, administration of thromboxane receptor antagonist, and endothelial-dependent vasodilation by acetylcholine infusion did not affect the renal vasoconstriction effect of CSA; renal response to CSA was prevented by blockade of the Ca channels with diltiazem, and the plasma endothelin concentration in renal venous blood increased significantly after injection of CSA. A dose-dependent increase in renal arterial resistance occurs with therapeutic blood levels of CSA. Renal vasoconstriction is induced by a local effect at the arterial wall, which is independent of neurogenic, adrenergic, and prostaglandin mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2279429536 created "2016-06-24" @default.
- W2279429536 creator A5005416698 @default.
- W2279429536 creator A5022745714 @default.
- W2279429536 creator A5062417923 @default.
- W2279429536 creator A5085718584 @default.
- W2279429536 date "1991-12-01" @default.
- W2279429536 modified "2023-09-27" @default.
- W2279429536 title "Dose-dependent effect of cyclosporin on renal arterial resistance in dogs" @default.
- W2279429536 doi "https://doi.org/10.1152/ajpheart.1991.261.6.h1791" @default.
- W2279429536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1661090" @default.
- W2279429536 hasPublicationYear "1991" @default.
- W2279429536 type Work @default.
- W2279429536 sameAs 2279429536 @default.
- W2279429536 citedByCount "10" @default.
- W2279429536 countsByYear W22794295362012 @default.
- W2279429536 crossrefType "journal-article" @default.
- W2279429536 hasAuthorship W2279429536A5005416698 @default.
- W2279429536 hasAuthorship W2279429536A5022745714 @default.
- W2279429536 hasAuthorship W2279429536A5062417923 @default.
- W2279429536 hasAuthorship W2279429536A5085718584 @default.
- W2279429536 hasConcept C120770815 @default.
- W2279429536 hasConcept C126322002 @default.
- W2279429536 hasConcept C134018914 @default.
- W2279429536 hasConcept C142225936 @default.
- W2279429536 hasConcept C146957229 @default.
- W2279429536 hasConcept C2776634560 @default.
- W2279429536 hasConcept C2779961880 @default.
- W2279429536 hasConcept C2780091579 @default.
- W2279429536 hasConcept C42219234 @default.
- W2279429536 hasConcept C58245268 @default.
- W2279429536 hasConcept C71924100 @default.
- W2279429536 hasConcept C84393581 @default.
- W2279429536 hasConceptScore W2279429536C120770815 @default.
- W2279429536 hasConceptScore W2279429536C126322002 @default.
- W2279429536 hasConceptScore W2279429536C134018914 @default.
- W2279429536 hasConceptScore W2279429536C142225936 @default.
- W2279429536 hasConceptScore W2279429536C146957229 @default.
- W2279429536 hasConceptScore W2279429536C2776634560 @default.
- W2279429536 hasConceptScore W2279429536C2779961880 @default.
- W2279429536 hasConceptScore W2279429536C2780091579 @default.
- W2279429536 hasConceptScore W2279429536C42219234 @default.
- W2279429536 hasConceptScore W2279429536C58245268 @default.
- W2279429536 hasConceptScore W2279429536C71924100 @default.
- W2279429536 hasConceptScore W2279429536C84393581 @default.
- W2279429536 hasIssue "6" @default.
- W2279429536 hasLocation W22794295361 @default.
- W2279429536 hasLocation W22794295362 @default.
- W2279429536 hasOpenAccess W2279429536 @default.
- W2279429536 hasPrimaryLocation W22794295361 @default.
- W2279429536 hasRelatedWork W1264394838 @default.
- W2279429536 hasRelatedWork W1899585848 @default.
- W2279429536 hasRelatedWork W2003602108 @default.
- W2279429536 hasRelatedWork W2037340906 @default.
- W2279429536 hasRelatedWork W2052195065 @default.
- W2279429536 hasRelatedWork W2062130425 @default.
- W2279429536 hasRelatedWork W2067219279 @default.
- W2279429536 hasRelatedWork W2081653245 @default.
- W2279429536 hasRelatedWork W2410655377 @default.
- W2279429536 hasRelatedWork W2914428858 @default.
- W2279429536 hasVolume "261" @default.
- W2279429536 isParatext "false" @default.
- W2279429536 isRetracted "false" @default.
- W2279429536 magId "2279429536" @default.
- W2279429536 workType "article" @default.